Targeted Temperature Management at 33°C Versus Controlled Normothermia for In-hospital Cardiac Arrest (NCT07086703)
🩺 Plain-English Summary (8th-Grade Level)
The IH-TTM trial is designed to determine whether survival with a favorable neurological outcome is improved by induced hypothermia at 33°C in comatose critically ill patients admitted after resuscitated in-hospital cardiac arrest (IHCA). Recent evidence suggests that targeted temperature management (TTM) at 33°C may provide no survival benefits compared to controlled normothermia in unselected patients with out-of-hospital cardiac arrest (OHCA). However, this evidence is relevant only to OHCA of presumed cardiac origin, chiefly witnessed and immediately followed by resuscitation efforts. Only scant data are available for cardiac arrest (CA) of other origins and for IHCA. In a randomized clinical trial of patients with CA in an initial non-shockable rhythm, the subgroup with IHCA had significantly better outcomes when treated with TTM at 33°C versus controlled normothermia; nevertheless, the sample size was limited. Another randomized controlled trial done specifically in patients with IHCA failed to show benefits of TTM at 33°C compared to controlled normothermia but was underpowered. Thus, whether therapeutic hypothermia is indicated after IHCA remains unclear. IH-TTM will be the largest trial assessing TTM after IHCA.
Who can join: Review the eligibility criteria below.
Location: Hôpital Erasme — Brussels
Age range: 18 Years
🧪 Interventions in This Study
- Induced hypothermia at 33°C (OTHER)
- Control normothermia (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (32 Sites)
Showing the first 25 of 32 sites.
- Hôpital Erasme — Brussels,
- CHU Charleroi — Charleroi,
- Hôpital Universitaire de Gand — Ghent,
- Hôpital Universitaire de Bruxelles — Jette,
- Clinique Saint-PIerre — Ottignies,
- CH d'Angoulême — Angoulême,
- CH Dubois Brive — Brive-la-Gaillarde,
- CHU de Caen — Caen,
- Hôpital Simone Veil — Cannes,
- CH Public du Cotentin — Cherbourg,
- CHU Clermont-Ferrand — Clermont-Ferrand,
- CHU Bocage — Dijon,
- CHD Vendée — La Roche-sur-Yon,
- Hôpital André Mignot — Le Chesnay,
- CHRU- Hôpital Roger Salengro — Lille,
- CHU Dupuytren — Limoges,
- Hôpital Edouard Herriot — Lyon,
- APHM - Hôpital Nord — Marseille,
- Hôpital Privé Jacques Cartier — Massy,
- CHU de Nantes — Nantes,
- Hôpital de l'Archet — Nice,
- CHR d'Orléans — Orléans,
- APHP-Hôpital Saint-Antoine — Paris,
- APHP- Hôpital Cochin — Paris,
- APHP - Hôpital Ambroise Paré — Paris,
📞 Contact the Study Coordinator
Phone: +33(0)240087386
Email: jeanbaptiste.lascarrou@chu-nantes.fr
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Cardiac Arrest
- RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems — Durham, North Carolina
- Sustained Inflation and Chest Compression vs 3:1 C:V Ratio in Asphyxiated Newborns — Edmonton,
- Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled Trial — Toronto, Ontario
- Impact of Aerosol Box Use During Cardiopulmonary Arrest: A Multicenter Study — Los Angeles, California
- Early Amiodarone in Shockable Cardiac Arrest — Portland, Oregon
Explore by condition: All Cardiac Arrest clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.