Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX) (NCT07100990)
A Randomized Controlled, Open-Label, Rater-Blinded Pragmatic Trial, Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this research is to evaluate if early vs rescue Therapeutic Plasma Exchange (PLEX) treatment algorithm leads to better visual outcomes in severe Optic Neuritis and leads to better neurological disability outcomes in severe Transverse Myelitis.
Who can join: Review the eligibility criteria below.
Location: Mayo Clinic Arizona — Scottsdale, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (33 Sites)
Showing the first 25 of 33 sites.
- Mayo Clinic Arizona — Scottsdale, Arizona
- Loma Linda University — Loma Linda, California
- University of California, Davis — Sacramento, California
- University of Colorado - Anschutz Medical — Aurora, Colorado
- Yale University School of Medicine — North Haven, Connecticut
- Mayo Clinic Florida — Jacksonville, Florida
- University of Miami — Miami, Florida
- University of Illinois Chicago — Chicago, Illinois
- Northwestern University — Evanston, Illinois
- Indiana University — Indianapolis, Indiana
- University of Maryland, Baltimore — Baltimore, Maryland
- Johns Hopkins University — Baltimore, Maryland
- Medstar Health Research Institute — Columbia, Maryland
- Harvard University Massachusetts General Hospital — Boston, Massachusetts
- Boston Medical Center — Boston, Massachusetts
- Regents of the University of Michigan — Ann Arbor, Michigan
- Mayo Clinic in Rochester — Rochester, Minnesota
- University of Mississippi Medical Center — Jackson, Mississippi
- NYU Langone Health — New York, New York
- Icahn School of Medicine at Mount Sinai — New York, New York
- Columbia University — New York, New York
- Weill Cornell Medical College — New York, New York
- University of North Carolina School of Medicine — Chapel Hill, North Carolina
- Duke University Health System — Durham, North Carolina
- University Hospitals Cleveland Medical Center — Cleveland, Ohio
📞 Contact the Study Coordinator
Phone: (480) 684-3127
Email: wingerchuk.dean@mayo.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Optic Neuritis
- Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER) — San Francisco, California
- Efgartigimod for the Treatment of Acute Optic Neuritis — Boston, Massachusetts
- Privosegtor Investigation in Optic Neuropathies Efficacy Evaluation Research — Livonia, Michigan
Explore by condition: All Optic Neuritis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.