A Study to Assess Zipalertinib Versus Placebo in Participants With Early Stage NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection (NCT07128199)
A Randomized, Placebo-Controlled, Double-Blind, Multi-Center Phase 3 Study of Zipalertinib Versus Placebo in Early Stage NSCLC Patients With Uncommon EGFR Mutations Following Complete Tumor Resection (REZILIENT4)
๐ฉบ Plain-English Summary (8th-Grade Level)
The purpose of this study is to compare the efficacy of zipalertinib versus placebo in participants with early stage resected non-small cell lung cancer (NSCLC) harboring uncommon epidermal growth factor receptor mutation (EGFRmt).
Who can join: Review the eligibility criteria below.
Location: Alaska Oncology and Hematology โ Anchorage, Alaska
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (252 Sites)
Showing the first 25 of 252 sites.
- Alaska Oncology and Hematology โ Anchorage, Alaska
- City of Hope Comprehensive Cancer Center - Duarte โ Duarte, California
- City of Hope Comprehensive Cancer Center Orange County Lennar Foundation Cancer Center โ Irvine, California
- Scripps Clinic Torrey Pines โ La Jolla, California
- Kaiser Permanente - Vallejo Medical Center โ Vallejo, California
- Georgetown University School of Medicine โ Washington D.C., District of Columbia
- D&H Cancer Research Center - Margate โ Margate, Florida
- Alpha Oncology Research โ Orange City, Florida
- City of Hope - Atlanta โ Newnan, Georgia
- University of Illinois Medical Center โ Chicago, Illinois
- Profound Research LLC at Michigan Hematology and Oncology Consultants โ Dearborn, Michigan
- Henry Ford Health System โ Detroit, Michigan
- Memorial Sloan Kettering Cancer Center - Basking Ridge โ Basking Ridge, New Jersey
- Memorial Sloan Kettering Cancer Center - Monmouth โ Middletown, New Jersey
- Memorial Sloan Kettering Cancer Center - Bergen โ Montvale, New Jersey
- Memorial Sloan Kettering Cancer Center - Commack โ Commack, New York
- Memorial Sloan Kettering Cancer Center - Westchester โ East White Plains, New York
- Long Island Jewish Medical Center โ Lake Success, New York
- Perlmutter Cancer Center - 34th Street โ New York, New York
- Memorial Sloan Kettering Cancer Center - New York โ New York, New York
- Memorial Sloan Kettering Cancer Center - Nassau โ Uniondale, New York
- Atrium Health Wake Forest Baptist - Comprehensive Cancer Center โ Charlotte, North Carolina
- Durham Veterans Affairs Health Care System โ Durham, North Carolina
- Gabrail Cancer and Research Center โ Canton, Ohio
- Gibbs Cancer Center and Research Institute Spartanburg โ Spartanburg, South Carolina
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Lung Cancer
- Implementation Strategies for Monitoring Adherence in Real Time โ Philadelphia, Pennsylvania
- Early Detection of Lung Cancer โ Nashville, Tennessee
- Improving Utilization of Lung Cancer Screening in Underserved PA Populations โ Allentown, Pennsylvania
- Effect of Pulmonary Rehabilitation on Surgical Outcomes in the Cancer Setting โ Houston, Texas
- Testing the Engaged Approach to Lung Cancer Screening โ Denver, Colorado
- Real-Time Image Guided Lymphatic Mapping and Nodal Targeting in Lung Cancer โ Boston, Massachusetts
Explore by condition: All Lung Cancer clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.