Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery (NCT07140172)
Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery: An International, Randomized Superiority Trial (OPBC-10/ NOAX)
🩺 Plain-English Summary (8th-Grade Level)
This trial is to investigate if in patients with clinically node positive breast cancer undergoing upfront surgery, treatment with TAS and ART is superior to ALND in terms of arm-related Quality of Life (QoL) and occurrence of lymphedema two years after randomization.
Who can join: Review the eligibility criteria below.
Location: Walter Reed National Military Medical Center — Bethesda, Maryland
Age range: 18 Years
🧪 Interventions in This Study
- Axillary lymph node dissection (ALND) (PROCEDURE)
- Axillary radiotherapy (ART) (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (54 Sites)
Showing the first 25 of 54 sites.
- Walter Reed National Military Medical Center — Bethesda, Maryland
- Duke University/Duke Cancer Center — Durham, North Carolina
- Fox Chase Cancer Center — Philadelphia, Pennsylvania
- Swedish Cancer Institute — Seattle, Washington
- KH Dornbirn — Dornbirn,
- LKH Feldkirch — Feldkirch,
- MUI - Univ. Klinik f. Frauenheilkunde Innsbruck — Innsbruck,
- Ordensklinikum Linz — Linz,
- Medical University Vienna, Department of Gynecology — Vienna,
- Medical University Vienna, Department of Surgery — Vienna,
- CIUSSS du Centre Ouest-de-l 'Ile-de-Montréal — Montreal,
- Breast Centre of Clinical Hospital, Rijeka — Rijeka,
- University Hospital Heidelberg, Women's Clinic — Heidelberg,
- Brustzentrum Heidelberg Klinik St. Elisabeth GmbH — Heidelberg,
- Breast Center Osnabrück — Osnabrück,
- HELIOS Universitätsklinikum Wuppertal — Wuppertal,
- "Alexandra" Hospital, Athens — Athens,
- University Hospital of Heraklion — Heraklion,
- University Hospital of Larissa — Larissa,
- Cork University Hospital — Cork,
- Beaumont Hospital Dublin — Dublin,
- St- Luke's Hospital Dublin — Dublin,
- St. James's Hospital Dublin — Dublin,
- St. Vincent's University Hospital — Dublin,
- University Hospital Galway — Galway,
📞 Contact the Study Coordinator
Phone: +41 61 328 61 49
Email: walter.weber@usb.ch
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.