Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression (NCT07166289)
Parsing Mechanistic Relationships Between Circuits and Negative Valence System Behaviors in Treatment-Resistant Depression With Ultrasound Neuromodulation
🩺 Plain-English Summary (8th-Grade Level)
Approximately one third of individuals with Major Depressive Disorder (MDD) are considered treatment-resistant, subject to severe disability and risk of suicide, and exhibit symptoms anchored in abnormalities of Research Domain Criteria (RDoC) Negative Valence Systems behavioral processes. In the present study we plan to use low-intensity focused ultrasound in 120 persons with treatment-resistant MDD to modulate deep white matter tracts connecting the thalamus and different regions of the prefrontal cortex reversibly and non-invasively, with the aim of assigning a causal, mechanistic role to large scale brain circuits in the production of those critical behavioral abnormalities. A successful study will help to attain the precise definition of neuromodulation targets for this clinical population in utter need of help.
Who can join: Review the eligibility criteria below.
Location: Laureate Institute for Brain Research — Tulsa, Oklahoma
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
- Low-intensity focused ultrasound (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Laureate Institute for Brain Research — Tulsa, Oklahoma
📞 Contact the Study Coordinator
Phone: (918) 502-5119
Email: sguinjoan@laureateinstitute.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Treatment-Resistant Depression
- Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression — Toronto, Ontario
- Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression — Toronto, Ontario
- Physical Activity Program for TRD — Toronto, Ontario
- Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression — Toronto, Ontario
Explore by condition: All Treatment-Resistant Depression clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.