Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease (NCT07181109)
ZENITH: A Phase 3 Global, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Zilebesiran in Addition to Standard of Care in Reducing Major Adverse Cardiovascular Events in Adult Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) events. This is an event-driven study that will continue until the targeted number of positively adjudicated primary endpoint clinical outcome events (COEs) have been reached.
Who can join: Review the eligibility criteria below.
Location: Clinical Trial Site — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1105 Sites)
Showing the first 25 of 1105 sites.
- Clinical Trial Site — Birmingham, Alabama
- Clinical Trial Site — Birmingham, Alabama
- Clinical Trial Site — Birmingham, Alabama
- Clinical Trial Site — Fairhope, Alabama
- Clinical Trial Site — Foley, Alabama
- Clinical Trial Site — Huntsville, Alabama
- Clinical Trial Site — Huntsville, Alabama
- Clinical Trial Site — Sheffield, Alabama
- Clinical Trial Site — Chandler, Arizona
- Clinical Trial Site — Gilbert, Arizona
- Clinical Trial Site — Glendale, Arizona
- Clinical Trial Site — Mesa, Arizona
- Clinical Trial Site — Phoenix, Arizona
- Clinical Trial Site — Phoenix, Arizona
- Clinical Trial Site — Sun City, Arizona
- Clinical Trial Site — Sun City West, Arizona
- Clinical Trial Site — Tempe, Arizona
- Clinical Trial Site — Tucson, Arizona
- Clinical Trial Site — Tucson, Arizona
- Clinical Trial Site — Tucson, Arizona
- Clinical Trial Site — Yuma, Arizona
- Clinical Trial Site — Little Rock, Arkansas
- Clinical Trial Site — Little Rock, Arkansas
- Clinical Trial Site — Little Rock, Arkansas
- Clinical Trial Site — Beverly Hills, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All High Risk Cardiovascular Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.