SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes (NCT07187531)
A Phase 2b, Randomised, Double-Blind, Placebo-Controlled, Parallel-Arm Dose Finding Study Evaluating the Efficacy and Safety of SAB-142 for Delaying the Progression of Type 1 Diabetes (T1D) in Patients With Stage 3 New Onset of Type 1 Diabetes (NOT1D)
🩺 Plain-English Summary (8th-Grade Level)
This is a Phase 2b, investigator- and participant-blinded, placebo-controlled, parallel-arm study to evaluate the efficacy, safety and tolerability of SAB 142 in patients with Stage 3 New Onset of Type 1 Diabetes (NOT1D).
Who can join: Review the eligibility criteria below.
Location: University of California San Francisco Benioff Children's Hospital — San Francisco, California
Age range: 5 Years to 40 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (70 Sites)
Showing the first 25 of 70 sites.
- University of California San Francisco Benioff Children's Hospital — San Francisco, California
- San Jose Clinical Trials, LLC — San Jose, California
- University of Colorado - Barbara Davis Center for Diabetes — Aurora, Colorado
- University of Florida College of Medicine — Gainesville, Florida
- University of Miami - Gables One Tower — Miami, Florida
- Children's Healthcare of Atlanta (CHOA) - Center for Advanced Pediatrics — Atlanta, Georgia
- IUH - Riley Hospital for Children - Riley Outpatient Center - Pediatric Diabetes & Endocrinology — Indianapolis, Indiana
- Harvard Medical School - Joslin Diabetes Center and Joslin Clinical (JDS) — Boston, Massachusetts
- Children's Mercy Hospital Kansas City - Pediatric Care Clinic — Kansas City, Missouri
- University of New Mexico Hospital — Albuquerque, New Mexico
- University at Buffalo MD Physicians Group — Buffalo, New York
- Asheville Clinical Research — Asheville, North Carolina
- N.C. Children's Hospital - Children's Specialty Clinics - Chapel Hill at Carolina Pointe II — Chapel Hill, North Carolina
- Sanford Medical Center Fargo — Fargo, North Dakota
- The Children's Hospital of Philadelphia — Philadelphia, Pennsylvania
- UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania
- Children's Medical Centre Dallas — Dallas, Texas
- Cook Children's Medical Center — Fort Worth, Texas
- Texas Children's Hospital - Clinical Care Center - Pediatric Renal Clinic — Houston, Texas
- San Antonio Clinical Trials — San Antonio, Texas
- University of Virginia Health System - Pediatric Diabetes Clinic — Charlottesville, Virginia
- Benaroya Research Institute at Virginia Mason — Seattle, Washington
- Mary Bridge Children's Outpatient Center - Tacoma — Tacoma, Washington
- Queensland Children's Hospital — Brisbane,
- Perth Children's Hospital — Nedlands,
📞 Contact the Study Coordinator
Phone: (844) 763-1890
Email: SAFEGUARD@sab.bio
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Diabetes Inspired Culinary Education (DICE): Culinary Medicine Intervention for At-Risk Youth With Type 1 Diabetes — Cleveland, Ohio
- GO TEAM: Glucose Optimization Through Technology Assisted Management — Cleveland, Ohio
- REAL-Fam Feasibility Study for Youth Diabetes Management — Chapel Hill, North Carolina
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Explore by condition: All Type 1 Diabetes clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.