🏛️ Verified NIH Record • Updated 2026-08-26

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer (NCT07213674)

A Phase 3, Open-label, Multicenter, Randomized Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

🟢 Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Amgen

🩺 Plain-English Summary (8th-Grade Level)

The primary objective of this study is to compare overall survival (OS) in participants receiving xaluritamig plus abiraterone against investigator's choice (docetaxel, cabazitaxel, or abiraterone).

Who can join: Review the eligibility criteria below.

Location: City of Hope Cancer Center Phoenix — Goodyear, Arizona

Age range: 18 Years

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (151 Sites)

Showing the first 25 of 151 sites.

  • City of Hope Cancer Center Phoenix — Goodyear, Arizona
  • University of Arizona Cancer Center — Tucson, Arizona
  • City of Hope National Medical Center — Duarte, California
  • City of Hope Orange County Lennar Foundation Cancer Center — Duarte, California
  • Providence Saint Jude Medical Center — Fullerton, California
  • University of California Irvine — Orange, California
  • University of California San Francisco — San Francisco, California
  • Providence Saint Johns Health Center — Santa Monica, California
  • Rocky Mountain Cancer Centers — Denver, Colorado
  • Hartford HealthCare Cancer Institute at Hartford Hospital — Hartford, Connecticut
  • Medical Oncology Hematology Consultants Helen F Graham Cancer Center — Newark, Delaware
  • Moffitt Cancer Center — Tampa, Florida
  • City of Hope Atlanta — Newnan, Georgia
  • University of Illinois Chicago — Chicago, Illinois
  • Midwestern Regional Medical Center dba City of Hope Chicago — Zion, Illinois
  • University of Kansas Medical Center — Westwood, Kansas
  • University of Louisville Health - James Graham Brown Cancer Center — Louisville, Kentucky
  • Norton Cancer Institute — Louisville, Kentucky
  • University of Maryland Greenebaum Cancer Center — Baltimore, Maryland
  • Johns Hopkins Hospital Sidney Kimmell Comprehensive Cancer Center — Baltimore, Maryland
  • Barbara Ann Karmanos Cancer Institute — Lansing, Michigan
  • Minnesota Oncology Hematology PA — Minneapolis, Minnesota
  • University of Minnesota Medical Center Fairview — Minneapolis, Minnesota
  • Hematology Oncology Association of Central New York — East Syracuse, New York
  • Memorial Sloan Kettering Cancer Center — New York, New York

📞 Contact the Study Coordinator

Phone: (866) 572-6436

Email: medinfo@amgen.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗