🏛️ Verified NIH Record • Updated 2026-08-26
Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans (NCT07216781)
Evaluating the Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans: An Interventional, Non-Placebo-Controlled Pilot Phase Study
🔵 Active, Not Recruiting Phase1 📋 Clinical Research Protocol Sponsor: Minicircle
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to investigate the safety and efficacy of a gene therapy for Klotho, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of the Klotho gene therapy.
Who can join: Review the eligibility criteria below.
Location: Apeiron Center — Austin, Texas
Age range: 23 Years to 90 Years
🧪 Interventions in This Study
- Injectable Plasmid Klotho Gene Therapy (GENETIC)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- Apeiron Center — Austin, Texas
- GARM Clinic — Roatán, Bay Islands
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.