A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis (NCT07226895)
A Study to Explore Changes in Cognitive, Clinical, Biological and Digital Measures Following 8 Weeks of Twice-daily Dosing of MT1988 and to Evaluate Safety & Tolerability of MT1988, in Participants at Clinical High Risk (CHR) for Psychosis
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to learn how tests undertaken by people at high risk of developing psychosis (aged 17 to 30 years old) change when those people are given the study drug MT1988 daily for 8 weeks. This will help identify tests that could be used in later trials developing treatments for symptoms in people at high risk of developing psychosis, to measure whether those new treatments are effective. The main question this trial aims to answer is: Can any of the tests (biomarkers) used in this study detect changes in participants dosed with one of two different dose levels of MT1988? Researchers will compare the results from two dose levels of MT1988 to a placebo group. Researchers do not expect to see the test results change in participants taking placebo and this will be compared to changes expected in test results in participants taking MT1988. Participants will: * take a dose of MT1988 or placebo twice per day for 8 weeks * attend clinic appointments every two weeks to undertake assessments * report any side effects they experience to the researchers
Who can join: Review the eligibility criteria below.
Location: University of California, Irvine — Irvine, California
Age range: 17 Years to 30 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (15 Sites)
- University of California, Irvine — Irvine, California
- University of California — Los Angeles, California
- University of California, San Francisco — San Francisco, California
- Yale University Conneticut Mental Health Center — New Haven, Connecticut
- Beth Israel Deaconess Medical Center — Boston, Massachusetts
- Washington University — St Louis, Missouri
- Northwell Health — Glen Oaks, New York
- Columbia University — New York, New York
- Icahan School of Medicine at Mount Sinai — New York, New York
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina
- Ohio State University — Columbus, Ohio
- Prevention Science Institute — Eugene, Oregon
- University of Pennsylvania — Philadelphia, Pennsylvania
- Temple University — Philadelphia, Pennsylvania
- University of Pittsburgh School of Medicine — Pittsburgh, Pennsylvania
📞 Contact the Study Coordinator
Phone: +447539430768
Email: info@monumenttx.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Clinical High Risk for Psychosis (CHR)
- Digital Dialectical Behavioural Therapy (d-DBT) for Youth at Clinical High Risk (CHR) for Psychosis — Toronto, Ontario
- Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for Psychosis — Los Angeles, California
- Stratification and Treatment in Early Psychosis Study - PROMOTE — Vienna,
- Telehealth Cognitive Behavioral Therapy for Youth at Risk for Psychosis — New York, New York
- Accelerated Neuromodulation Therapy and Neurocomputational Biomarkers in Individuals at Clinical High Risk for Psychosis — Verdun, Quebec
Explore by condition: All Clinical High Risk for Psychosis (CHR) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.