๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-21

Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC) (NCT07252232)

RASolute 304: A Phase 3 Multicenter, Open-label, Randomized, 2-Arm Study of Adjuvant Daraxonrasib Versus Standard of Care Observation Following Completion of Neoadjuvant and/or Adjuvant Chemotherapy in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

๐ŸŸข Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Revolution Medicines, Inc.

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard of care (SOC) observation only.

Who can join: Review the eligibility criteria below.

Location: Mayo Clinic โ€” Phoenix, Arizona

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (66 Sites)

Showing the first 25 of 66 sites.

  • Mayo Clinic โ€” Phoenix, Arizona
  • UC San Diego Moores Cancer Center โ€” La Jolla, California
  • Cedars-Sinai Cancer at Cedars-Sinai Medical Center โ€” Los Angeles, California
  • University of California, Los Angeles โ€” Los Angeles, California
  • Stanford Cancer Institute โ€” Palo Alto, California
  • University of California, San Francisco โ€” San Francisco, California
  • Rocky Mountain Cancer Centers, LLP โ€” Lakewood, Colorado
  • Hartford Healthcare โ€” Hartford, Connecticut
  • Mayo Clinic โ€” Jacksonville, Florida
  • University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center โ€” Miami, Florida
  • Florida Cancer Specialists โ€” St. Petersburg, Florida
  • Winship Cancer Institute, Emory University โ€” Atlanta, Georgia
  • Community Health Network โ€” Indianapolis, Indiana
  • University of Kansas Medical Center Research Institute, Inc. โ€” Lawrence, Kansas
  • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins & Sibley Memorial Hospital โ€” Baltimore, Maryland
  • Massachusetts General Hospital โ€” Boston, Massachusetts
  • Dana Farber Cancer Institute (DFCI) โ€” Boston, Massachusetts
  • Mayo Clinic Cancer Center โ€” Rochester, Minnesota
  • Saint Luke's Cancer Institute โ€” Kansas City, Missouri
  • University of Nebraska Medical Center โ€” Omaha, Nebraska
  • Comprehensive Cancer Centers of Nevada โ€” Las Vegas, Nevada
  • Laura and Issac Perlmutter Cancer Center at NYU Langone-Ambulatory Care Center โ€” New York, New York
  • Columbia University Medical Center โ€” New York, New York
  • Memorial Sloan Kettering Cancer Center โ€” New York, New York
  • University of Rochester Medical Center โ€” Rochester, New York

๐Ÿ“ž Contact the Study Coordinator

Phone: (480) 342-4800

Email: bekaii-saab.tanios@mayo.edu

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—