An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer (NCT07255729)
Machine Learning-Based Exosomal microRNA Signature for Preoperative Staging and Chemotherapy Eligibility in Colon Cancer
π©Ί Plain-English Summary (8th-Grade Level)
Recent studies have highlighted the potential benefits of neoadjuvant chemotherapy (NAC) in colon cancer; however, its indication is generally limited to cases corresponding to pathological stage IIB or higher. Accurately identifying such high-risk cases before surgery remains challenging using conventional clinical diagnostics alone. Therefore, we hypothesized that integrating molecular biomarkers with preoperative clinical assessment could provide a more precise and sensitive evaluation of tumor aggressiveness. In this context, we focused on exosomal microRNAs, which are actively secreted from tumor cells and remain stable in circulation, and aimed to develop a machine learning-based biomarker panel. To achieve this, we initiated a multicenter study utilizing preoperative plasma samples to establish a reliable biomarker model for risk stratification and treatment decision-making in colon cancer.
Who can join: Review the eligibility criteria below.
Location: City of Hope Medical Center β Duarte, California
Age range: 18 Years
π§ͺ Interventions in This Study
- Diagnostic Test: EXPOSE assayοΌSmall RNA-seq of exosomal miRNAsοΌ (DIAGNOSTIC_TEST)
- Diagnostic Test: EXPOSE RT-qPCR panel (DIAGNOSTIC_TEST)
π "Do I Qualify?" β 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria β
π All Participating Trial Locations (1 Sites)
- City of Hope Medical Center β Duarte, California
π Contact the Study Coordinator
Phone: (626) 218-3452
Email: ajgoel@coh.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
π° Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA Β§ 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Colon Cancer
- CEND-1 in Combination with Neoadjuvant FOLFIRINOX with or Without Panitumumab β Fairway, Kansas
- A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver Tumors β Basking Ridge, New Jersey
- Voyage: Real-World Impact of the Multi-target Stool DNA Test on CRC Screening and Mortality β Rochester, Minnesota
- The Exercise And Colorectal Cancer Treatment Trial β Baton Rouge, Louisiana
- Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer β Atlanta, Georgia
- The Phoenix Trial: Phase II Trial of Cemiplimab for the Non-operative Management of Localized dMMR Colon Cancer β Gilbert, Arizona
Explore by condition: All Colon Cancer clinical trials
π‘ How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.