EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors (NCT07262619)
A Multicenter, Multi-Part, Phase 1/2 Study of EIK1005 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors, Including Checkpoint Inhibitor Naïve Participants With Microsatellite Instability High (MSI-H) or Mismatch Repair Deficient (dMMR) Tumors
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to determine the most effective dose of EIK1005 that a person can take safely. Additionally, this study will test how well EIK1005 is tolerated alone and in combination with pembrolizumab in treating patients with advanced cancer.
Who can join: Review the eligibility criteria below.
Location: Morristown Medical Center — Morristown, New Jersey
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (10 Sites)
- Morristown Medical Center — Morristown, New Jersey
- Memorial Sloan Kettering Cancer Center (MSKCC) — New York, New York
- University of Texas MD Anderson Cancer Center — Houston, Texas
- GenesisCare North Shore (Oncology) — Saint Leonards, New South Wales
- Calvary Mater Newcastle Hospital — Waratah, New South Wales
- Grampians Health — Ballarat, Victoria
- Chris O'Brien Lifehouse (Sydney Cancer Centre) — Camperdown, Victoria
- Oncology Clinics Victoria (OCV) - Cabrini Brighton Hospital — Frankston, Victoria
- Peninsula and Southeast Oncology (PASO) Medical — Frankston, Victoria
- Health New Zealand — Wellington,
📞 Contact the Study Coordinator
Phone: (347) 806-4584
Email: mamedea@eikontx.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Advanced Solid Tumors clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.