Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition (NCT07265323)
Effect of Physiologic Insulin Intervention on Insulin Sensitivity and Cognition
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention. The main questions it aims to answer are: Does the intervention improve insulin sensitivity (how the body uses glucose)? Does the intervention improve cognition, measured by the Montreal Cognitive Assessment (MoCA) and the Revised Memory and Behavior Problems Checklist (RMBPC)? What changes occur in brain glucose uptake (FDG-PET)? Participants will: Receive the intervention once a week for 6 months, with each session lasting up to 2 hours Complete cognitive assessments. Adverse events will be assessed throughout the study.
Who can join: Review the eligibility criteria below.
Location: Pennington Biomedical Research Center — Baton Rouge, Louisiana
Age range: 18 Years
🧪 Interventions in This Study
- Physiological Insulin Intervention (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Pennington Biomedical Research Center — Baton Rouge, Louisiana
📞 Contact the Study Coordinator
Phone: (225) 763-2584
Email: Tim.Gilbert@pbrc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Alzheimer s Disease
- Ultrasonic Debris Clearance to Promote Brain Resilience — Stanford, California
- Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia — Toronto, Ontario
- PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI) — Bethesda, Maryland
- Crownlands Observing Progression With Neurons Study — Germantown, Maryland
- Development of a Home Test for Measuring Blood P-tau217 in Alzheimer's Disease Using the Tasso Lancet Device — Chicago, Illinois
Explore by condition: All Alzheimer s Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.