A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial) (NCT07286578)
A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium
🩺 Plain-English Summary (8th-Grade Level)
The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) will improve procedural efficiency and effectiveness compared with the current standard of care (IVUS-guided PCI) while achieving similar clinical outcomes in patients with hemodynamically significant calcified coronary artery disease.
Who can join: Review the eligibility criteria below.
Location: Bringham and Women's Hospital — Boston, Massachusetts
Age range: 18 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (14 Sites)
- Bringham and Women's Hospital — Boston, Massachusetts
- Minneapolis Heart Institute — Minneapolis, Minnesota
- HACKENSACK MERIDIAN HEALTH, Inc — Jersey City, New Jersey
- Columbia University Irving Medical Center/NewYork-Presbyterian Hospital — New York, New York
- Weill Medical College of Cornell University — New York, New York
- Azorg Hospital, Aalst — Aalst,
- Hospital Universitari Vall Hebron — Barcelona,
- Hospital Universitario de Leon — León,
- Hospital Universitario La Paz — Madrid,
- University Hospitals of Leicester NHS Trust — Leicester,
- St Bartholomew's Hospital (Barts Health NHS Trust) — London,
- St George's University Hospitals NHS Foundations Trust — London,
- Newcastle Hospitals NHS Foundations Trust — Newcastle,
- John Radcliffe Hospital, Oxford — Oxford,
📞 Contact the Study Coordinator
Phone: 001 917 753 6695
Email: cfocella@crf.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.