🏛️ Verified NIH Record • Updated 2026-04-30
Comparative Immunogenicity of Respiratory Virus Vaccines (CIRV2) Study (NCT07287137)
IDCRP-154: Comparative Immunogenicity of Respiratory Virus Vaccines (CIRV2) Study
🔵 Active, Not Recruiting Phase4 💊 Investigational Drug / Biologic Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine
🩺 Plain-English Summary (8th-Grade Level)
CIRV2 is a Phase IV randomized, open-label, trial of FDA-approved COVID-19 and/or influenza vaccines (no more than minimal risk) with longitudinal follow-up. In 2025 CIRV2 will compare immunogenicity and reactogenicity of the recombinant Novavax COVID-19 vaccine and the mRNA Pfizer-BioNTech COVID-19 vaccine.
Who can join: Review the eligibility criteria below.
Location: Walter Reed National Military Medical Center — Bethesda, Maryland
Age range: 18 Years to 79 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Walter Reed National Military Medical Center — Bethesda, Maryland
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- A Safety, Reactogenicity and Immunogenicity Trial of RVX-sCPD9 Booster Intranasal COVID-19 Vaccine — New York, New York
- A Study Evaluating MDX2301 in Healthy Adults and Adults at Higher Risk for Severe COVID-19. — Las Vegas, Nevada
Explore by condition: All COVID -19 clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.