A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH) (NCT07288138)
A Phase 2a, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of a THRβ Agonist (ECC4703), an SSAO Inhibitor (ECC0509), and Their Combination in Adults With Presumed MASH
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of this trial is to evaluate the dose-dependent and comparative effects of ECC4703 (low and high dose), ECC0509 (low and high dose), and their combination on hepatic fat reduction as assessed by change in magnetic resonance imaging proton density fat fraction (MRI-PDFF) at Week 12.
Who can join: Review the eligibility criteria below.
Location: Arizona Liver Health — Chandler, Arizona
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (63 Sites)
Showing the first 25 of 63 sites.
- Arizona Liver Health — Chandler, Arizona
- Arizona Liver Health - Peoria — Peoria, Arizona
- Adobe Clinical Research, LLC — Tucson, Arizona
- Arizona Liver Health - Tucson — Tucson, Arizona
- Arkansas Gastroenterology, P.A — Little Rock, Arkansas
- ARcare Center for Clinical Research — Little Rock, Arkansas
- Om Research — Apple Valley, California
- ARK Clinical Research - Fountain Valley — Fountain Valley, California
- UCSD Medical Center — La Jolla, California
- Om Research — Lancaster, California
- Ark Clinical Research — Long Beach, California
- Knowledge Research Center — Orange, California
- Om Research — Victorville, California
- Synergy Healthcare — Bradenton, Florida
- Synergy Healthcare — Bradenton, Florida
- Health Awareness, Inc. — Jupiter, Florida
- Evolution Clinical Trials — Miami, Florida
- Floridian Clinical Research, LLC — Miami Lakes, Florida
- Ocala GI Research — Ocala, Florida
- Progressive Medical Research — Port Orange, Florida
- ClinCloud, LLC — Viera, Florida
- Metabolic Research Institute — West Palm Beach, Florida
- CenExel - iResearch — Decatur, Georgia
- Gastrointestinal Specialists of Georgia, PC — Marietta, Georgia
- Digestive Research Alliance of Michiana — South Bend, Indiana
📞 Contact the Study Coordinator
Phone: 86-21-61053022
Email: contact@eccogene.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Metabolic Dysfunction-associated Steatohepatitis
- A Pivotal Clinical Study to Investigate the Safety and Efficacy of Efimosfermin Compared With Placebo in Adult Participants With Compensated Cirrhosis Due to Metabolic Dysfunction-associated Steatohepatitis (MASH) — Miami, Florida
- A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH — Chandler, Arizona
- A Study to Investigate Safety and Efficacy of Efimosfermin Compared With Placebo in Adult Participants With Compensated Cirrhosis Due to Metabolic Dysfunction-associated Steatohepatitis (MASH) — Miami, Florida
Explore by condition: All Metabolic Dysfunction-associated Steatohepatitis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.