Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations (NCT07291037)
A Phase III, Randomised, Open-Label, Multicentre Study of Datopotamab Deruxtecan or Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous Non-Small Cell Lung Cancer Without Actionable Genomic Alterations (TROPION-Lung17)
🩺 Plain-English Summary (8th-Grade Level)
TROPION-Lung17 will measure the efficacy and safety of datopotamab deruxtecan (Dato-DXd) compared with docetaxel in patients with trophoblast cell surface protein 2 (TROP2) positive advanced or metastatic lung cancer without actionable genomic alterations (AGA).
Who can join: Review the eligibility criteria below.
Location: Research Site — Chandler, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (205 Sites)
Showing the first 25 of 205 sites.
- Research Site — Chandler, Arizona
- Research Site — Gilbert, Arizona
- Research Site — Goodyear, Arizona
- Research Site — Duarte, California
- Research Site — Irvine, California
- Research Site — La Jolla, California
- Research Site — Loma Linda, California
- Research Site — Los Angeles, California
- Research Site — San Diego, California
- Research Site — Grand Junction, Colorado
- Research Site — Wheat Ridge, Colorado
- Research Site — Newark, Delaware
- Research Site — Washington D.C., District of Columbia
- Research Site — Fort Myers, Florida
- Research Site — Jacksonville, Florida
- Research Site — St. Petersburg, Florida
- Research Site — Tampa, Florida
- Research Site — West Palm Beach, Florida
- Research Site — Marietta, Georgia
- Research Site — Newnan, Georgia
- Research Site — Chicago, Illinois
- Research Site — Chicago, Illinois
- Research Site — Niles, Illinois
- Research Site — Zion, Illinois
- Research Site — Louisville, Kentucky
📞 Contact the Study Coordinator
Phone: (877) 240-9479
Email: information.center@astrazeneca.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- HER3-DXd (Patritumab Deruxtecan; U3-1402) in Combination With Osimertinib in Subjects With Locally Advanced or Metastatic EGFR-mutated Non-Small Cell Lung Cancer — Santa Monica, California
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Explore by condition: All Non-small Cell Lung Cancer (NSCLC) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.