Study of VYD2311 for the Prevention of COVID-19 (NCT07298434)
A Phase 3, Randomized, Triple-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of VYD2311 for the Prevention of COVID-19 in Adults and Adolescents
🩺 Plain-English Summary (8th-Grade Level)
The main purpose of this study is to test an investigational drug known as VYD2311, which is being developed to lower the risk of getting COVID-19. VYD2311 is a monoclonal antibody that attaches to the virus that causes COVID-19 and helps block it from entering your cells. It is being tested in adults and adolescents at least 12 years old. Participants in this study will be given a "study drug" that will be either VYD2311 or placebo. The study drug will be given as a shot into the muscle in the participant's upper thigh or upper arm once a month with a total of 3 shots during the study. This study will help researchers see how well VYD2311 works to prevent COVID-19 during the 90 days after the first shot. The study will also look at the safety and tolerability of VYD2311, how the study drug is processed by the body (pharmacokinetics), how the immune system reacts to the study drug (immunogenicity), and how well VYD2311 can block the virus from infecting cells (neutralization). To do these tests, your blood will be drawn at certain times during the study.
Who can join: Review the eligibility criteria below.
Location: Invivyd Investigative Site — Long Beach, California
Age range: 12 Years to 100 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (20 Sites)
- Invivyd Investigative Site — Long Beach, California
- Inviviyd Investigative Site — San Diego, California
- Invivyd Investigative Site — Orlando, Florida
- Invivyd Investigative Site — Hinesville, Georgia
- Invivyd Investigative Site — Melrose Park, Illinois
- Invivyd Investigative Site — Lenexa, Kansas
- Invivyd Investigative Site — Silver Spring, Maryland
- Invivyd Investigative Site — Burlington, Massachusetts
- Invivyd Investigative Site — Southfield, Michigan
- Invivyd Investigative Site — Maplewood, Minnesota
- Invivyd Investigative Site — Independence, Missouri
- Invivyd Investigative Site — Jersey City, New Jersey
- Invivyd Investigative Site — The Bronx, New York
- Invivyd Investigative Site — Philadelphia, Pennsylvania
- Invivyd Investigative Site — Myrtle Beach, South Carolina
- Invivyd Investigative Site — Goodlettsville, Tennessee
- Invivyd Investigative Site — Houston, Texas
- Invivyd Investigative Site — Houston-2, Texas
- Invivyd Investigative Site — Irving, Texas
- Invivyd Investigative Site — Sugar Land, Texas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in COVID-19
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- Impact of Immunosuppression Adjustment on COVID-19 Vaccination Response in Kidney Transplant Recipients — Sacramento, California
- COVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE) — Bethesda, Maryland
- Identification and Characterization of SARS-CoV-2 Specific CD8 T Cells in Humans — Baltimore, Maryland
- Canadian Adaptive Platform Trial of Treatments for COVID-19 in Community Settings — Calgary, Alberta
- A Nasal Treatment for COVID-19 — Indianapolis, Indiana
Explore by condition: All COVID-19 clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.