The Effect of Hydration Status on Substrate Oxidation at Rest and During Light and Moderate Exercise (NCT07298863)
🩺 Plain-English Summary (8th-Grade Level)
Metabolic flexibility is the ability to properly switch between fat and carbohydrate stores to use for energy under different conditions (rest, feeding, exercise). Impairments in metabolic flexibility, also known as metabolic inflexibility, have been suggested to be an underlying cause of metabolic disease, like type 2 diabetes. Long-term low fluid intake may increase the risk of type 2 diabetes due to insulin resistance, a form of metabolic inflexibility. Further, low fluid intake has been shown to impair the ability to switch fuel preference during exercise. While there is some evidence that low fluid intake may lead to impaired metabolic flexibility, more information is needed. Therefore, the purpose of this study is to evaluate the impact of hydration status on substrate preference at rest and during exercise at varying intensities (light and moderate). Further, we will examine whether biological sex and menstrual cycle phase impact hydration and metabolism under these same conditions.
Who can join: Review the eligibility criteria below.
Location: Gatorade Sports Science Institute — Valhalla, New York
Age range: 18 Years to 35 Years
🧪 Interventions in This Study
- Part 1 - Exercise Trial (OTHER)
- Part 1 - Experimental Trial (OTHER)
- Part 2 - Oral Glucose Tolerance Test (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- Gatorade Sports Science Institute — Valhalla, New York
- PeakGenics Innovation InPeakGenics Innovation Incc — Newcastle, Ontario
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Hydration Status
- Hydrate Heroes for Improving Brain Function & Mood — Tampa, Florida
- Wearable Photoplethysmography for Non-invasive Hydration Assessment — Frisco, Texas
- A Clinical Trial to Explore the Efficacy of Two Investigational Products on Post-Exercise Hydration in Recreationally Active Healthy Adults — London, Ontario
Explore by condition: All Hydration Status clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.