Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity (NCT07311850)
Evaluating The Efficacy and Safety of MET097, a Fully-Biased, Ultra Long-Acting GLP-1RA, In People With Overweight or Obesity: A Phase 3, Multi-Center Randomized, Controlled Trial (VESPER-4)
🩺 Plain-English Summary (8th-Grade Level)
This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks. The primary endpoint will be assessed after 64 weeks of treatment with the secondary at 84 weeks.
Who can join: Review the eligibility criteria below.
Location: Headlands Research — Scottsdale, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (171 Sites)
Showing the first 25 of 171 sites.
- Headlands Research — Scottsdale, Arizona
- Alliance Research Institute — Canoga Park, California
- Rolling Oaks Radiology -Palms — Oxnard, California
- Clinical Innovations, Inc dba CITrials — Riverside, California
- Peninsula Headlands LLC — Rolling Hills, California
- Collaborative Neuroscience Research, LLC — Torrance, California
- CenExcel Rocky Mountain Clinical Research, LLC — Englewood, Colorado
- Research Centers of America — Hollywood, Florida
- Future Medical Research (Civia Health) — Longwood, Florida
- Advanced Clinical Research — Miami, Florida
- Oviedo Medical Research — Oviedo, Florida
- CenExel FCR - ForCare Clinical Research — Tampa, Florida
- DelRicht Research — Atlanta, Georgia
- CenExel iResearch, LLC — Savannah, Georgia
- CenExel CBH Health — Gaithersburg, Maryland
- Clinical Research Professionals — Chesterfield, Missouri
- Upgrade Performance Institute — Elkhorn, Nebraska
- Quality Clinical Research Inc — Omaha, Nebraska
- Primary clinical Research — Papillion, Nebraska
- Hassman Research Institute — Marlton, New Jersey
- Forum Health Cary — Cary, North Carolina
- Eximia EquiHealth Research — Durham, North Carolina
- Sahana Optometry PLLC dba Family Eye Wellness — Holly Springs, North Carolina
- TMA Headlands LLC - Wilmington — Wilmington, North Carolina
- TMA Headlands LLC — Wilmington, North Carolina
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.