๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-06-15

A Clinical Study of MK-4082 in Healthy Overweight Participants (MK-4082-002) (NCT07388667)

A Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MK-4082 in Healthy Overweight/Obese Participants

๐Ÿ”ต Active, Not Recruiting Phase1 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Merck Sharp & Dohme LLC

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

Researchers are looking for new weight loss medicines for people with higher body weight. The study medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a study medicine to people with a health condition, researchers first do studies to find a safe dose level (amount) of the study medicine that can be used in future studies. The goals of this study are to learn about: * The safety of MK-4082 and if people tolerate it * What happens to different MK-4082 dose levels in a person's body over time

Who can join: Review the eligibility criteria below.

Location: Anaheim Clinical Trials ( Site 0005) โ€” Anaheim, California

Age range: 18 Years to 60 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (5 Sites)

  • Anaheim Clinical Trials ( Site 0005) โ€” Anaheim, California
  • ProSciento Inc. ( Site 0002) โ€” Chula Vista, California
  • QPS-MRA, LLC ( Site 0003) โ€” South Miami, Florida
  • Bio-Kinetic Clinical Applications, LLD dba QPS-MO ( Site 0004) โ€” Springfield, Missouri
  • Hassman Research Institute Marlton Site ( Site 0006) โ€” Marlton, New Jersey

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Healthy clinical trials

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—