AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight (NCT07400107)
Efficacy and Safety of NNC0487-0111 s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Overweight or Obesity, and Type 2 Diabetes (AMAZE 8)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and type 2 diabetes. Participant will receive 2 injections every week: an active medicine and a placebo, both taken as injections under the skin once a week. The placebo is a treatment with no active medicine in it and will be given to all participants. In addition to placebo, participants will receive either of the active medicine NNC0487-0111 (the treatment being tested) or Semaglutide (an approved and commonly prescribed treatment used as comparator). Which treatment participants get is decided by chance.
Who can join: Review the eligibility criteria below.
Location: Encore Medical Research LLC — Hollywood, Florida
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (120 Sites)
Showing the first 25 of 120 sites.
- Encore Medical Research LLC — Hollywood, Florida
- Optimal Research Sites — Orange City, Florida
- Encore Medical Research of Weston — Weston, Florida
- Endocrine Research Solutions, Inc — Roswell, Georgia
- Elite Clinical Trials — Blackfoot, Idaho
- Endo And Metab Cons — Rockville, Maryland
- Arcturus Healthcare, PLC. — Troy, Michigan
- Velocity Clin Res, Dallas — Dallas, Texas
- Consano Clinical Research, LLC — Shavano Park, Texas
- Selma Medical Associates — Winchester, Virginia
- Centro de Investigaciones Metabólicas — Capital Federal, Buenos Aires
- Centro Médico CIMEL — Lanús Este, Buenos Aires
- Centro Médico Privado San Vicente Diabetes — Córdoba,
- Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda. — Porto Alegre, Rio Grande do Sul
- i9 Pesquisas Clínicas — Campinas, São Paulo
- CPQuali Pesquisa Clínica Ltda — São Paulo, São Paulo
- BR Trials - Ensaios Clínicos e Consultoria Ltda. — São Paulo, São Paulo
- Dr. Tatyana Metalova - AIPSMCE EOOD — Gotse Delchev,
- Medical centre Zdrave 1 OOD — Kozloduy,
- UMHAT Pulmed OOD - Pazardzhik, Department of Internal Diseases — Pazardzhik,
- MHAT Heart and Brain EAD - Pleven, Endocrinology and Metabolic Diseases — Pleven,
- DCC I- Pleven EOOD Endocrinology — Pleven,
- MHAT Knyaginya Klementina - Sofia EAD — Sofia,
- MHAT Sveta Sofia EOOD, Department of Endocrinology and Metabolic diseases — Sofia,
- Acibadem City Clinic UMHAT Tokuda EAD, Endocrinology — Sofia,
📞 Contact the Study Coordinator
Phone: (866) 867-7178
Email: clinicaltrials@novonordisk.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.