🏛️ Verified NIH Record • Updated 2026-04-22
Aleniglipron Phase 2 in Type 2 Diabetes Mellitus (NCT07400588)
A Phase 2, Randomized, Double-blind, Placebo-controlled, Study of the Safety and Tolerability of Aleniglipron in Adult Participants With Type 2 Diabetes Mellitus Living With Obesity or Overweight
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to assess the safety and tolerability of aleniglipron at doses up to 240 mg once daily (QD) in participants with T2DM who are living with obesity (body mass index \[BMI\] ≥ 30 kg/m2) or overweight (BMI ≥ 27 kg/m2).
Who can join: Review the eligibility criteria below.
Location: Research Site — Anniston, Alabama
Age range: 18 Years to 79 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (16 Sites)
- Research Site — Anniston, Alabama
- Research Site — Lake Forest, California
- Research Site — Lomita, California
- Research Site — Hazelwood, Missouri
- Research Site — Columbus, Ohio
- Research Site — Moncks Corner, South Carolina
- Research Site — Chattanooga, Tennessee
- Research Site — Knoxville, Tennessee
- Research Site — Austin, Texas
- Research Site — DeSoto, Texas
- Research Site — Houston, Texas
- Research Site — Mesquite, Texas
- Research Site — San Antonio, Texas
- Research Site — San Antonio, Texas
- Research Site — San Antonio, Texas
- Research Site — Tomball, Texas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Obese clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.