A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D) (NCT07400653)
EVALUATING THE EFFICACY AND SAFETY OF MET097, A FULLY-BIASED ULTRA LONG-ACTING GLP-1RA, IN PEOPLE WITH OVERWEIGHT OR OBESITY AND TYPE 2 DIABETES: A PHASE 3, MULTI-CENTER RANDOMIZED PLACEBO-CONTROLLED TRIAL (VESPER-5)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this clinical study is to learn about the safety and effects of the study medicine to help adults with obesity or overweight and type 2 diabetes lose weight. Being overweight or obese means carrying too much body weight. Type 2 diabetes is a condition where there is too much sugar in the blood. The study medicine is given by a shot under the skin in the belly area. The participants will be trained to do this at home once every week. About 660 out of 1000 adults will also receive the study medicine and about 330 out of 1000 adults will receive placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. The investigators will compare the experiences of people receiving the study medicine to those of the people who do not. This will help us assess if the study medicine is safe and effective. People will take part in this study for about 21 months. During this time, they will have about 14 study visits at the site and 5 over the phone.
Who can join: Review the eligibility criteria below.
Location: CenExel Anaheim Clinical Trials — Anaheim, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (183 Sites)
Showing the first 25 of 183 sites.
- CenExel Anaheim Clinical Trials — Anaheim, California
- Alliance Research Institute — Canoga Park, California
- Core Healthcare Group — Cerritos, California
- CenExel CNS - Collaborative Neuroscience Research — Los Alamitos, California
- Catalina Research Institute, LLC — Montclair, California
- Cure Clinical Research — Orange, California
- CenExel CIT — Riverside, California
- Lundquist Institute for Biomedical Innovation at Harbor- UCLA Medical Center — Torrance, California
- CenExcel Rocky Mountain Clinical Research, LLC — Englewood, Colorado
- CenExel Denver CO (Rocky Mountain Clinical Research) — Englewood, Colorado
- Neuro-Sight Vision Care — Lakewood, Colorado
- AMR Clinical — Fort Myers, Florida
- Pedro P. Ylisastigui, MD — Fort Myers, Florida
- Private Practice Adjacent to For Eyes Optical — Hialeah, Florida
- Miami Eye Institute — Hollywood, Florida
- Research Centers of America — Hollywood, Florida
- Future Medical Research (Civia Health) — Longwood, Florida
- Advanced Clinical Research — Miami, Florida
- Indago Research & Health Center, Inc — Miami Lakes, Florida
- Optimal Research Sites, LLC — Orange City, Florida
- Oviedo Medical Research — Oviedo, Florida
- CenExel FCR - ForCare Clinical Research — Tampa, Florida
- DelRicht Research — Atlanta, Georgia
- CenExel iResearch, LLC — Decatur, Georgia
- CenExel iResearch, LLC — Savannah, Georgia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Study to Explore the Safety and Efficacy of NT-0796 as an Adjunct to Semaglutide in Participants With Obesity (RESOLVE-2) — Mesa, Arizona
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Explore by condition: All Obesity clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.