🏛️ Verified NIH Record • Updated 2026-02-23
A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years (NCT07413666)
A Safety, Tolerability, Pharmacokinetic, Food Effect, and Proof-of-Concept Study of Single and Multiple Doses of ORX489 in Healthy Adults
🟢 Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: Centessa Pharmaceuticals (UK) Limited
🩺 Plain-English Summary (8th-Grade Level)
Characterize the safety, tolerability and pharmacokinetics of ORX489 following single and multiple doses.
Who can join: Review the eligibility criteria below.
Location: Celerion — Lincoln, Nebraska
Age range: 18 Years to 60 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Celerion — Lincoln, Nebraska
📞 Contact the Study Coordinator
Phone: (617) 468-5770
Email: ORX489-101study@centessa.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.