Evaluation of Brain MRI Changes in Cerebral Palsy Patients (NCT07433647)
Evaluation of Brain Changes in Cerebral Palsy Patients
🩺 Plain-English Summary (8th-Grade Level)
Cerebral palsy (CP) is a neurodevelopmental syndrome characterized by sensorimotor impairment that arises during early childhood defined as a static insult to the developing brain. A key part of the definition for CP is a non-progressive brain injury; however, as individuals with CP age, a functional decline greater than neurotypical individuals is often present. The investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time. This will be a single-center study that will compare retrospective clinical and imaging data with similar prospective data. The objective is to find out if people with Cerebral Palsy (CP) experience changes in the structures of their brain over time. A key part of the CP definition is that it is a non-progressive brain injury. However, as people with CP age, their function often deteriorates. This study seeks to determine whether changes in the brain structure may result in function changes, as they do in other types of brain injuries. The investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States, as well as locally. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.
Who can join: Review the eligibility criteria below.
Location: Weinberg Family Cerebral Palsy Center, Columbia University — New York, New York
Age range: 18 Years to 80 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Weinberg Family Cerebral Palsy Center, Columbia University — New York, New York
📞 Contact the Study Coordinator
Phone: (212) 305-2700
Email: jbc28@cumc.columbia.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Cerebral Palsy
- Sensorimotor Control During Postural Transitions in CP — Newark, Delaware
- Improving Activity in Individuals With Cerebral Palsy — Boys Town, Nebraska
- Neuromodulation of the Cortex and Spinal Cord — Boys Town, Nebraska
- Robotic Exoskeleton Gait Training in Adolescents With Cerebral Palsy — Boys Town, Nebraska
- Feasibility and Reliability of the Melbourne Assessment-2 (MA-2) for Telehealth — Columbus, Ohio
- Feasibility and Effectiveness of Therapy Together — Frisco, Texas
Explore by condition: All Cerebral Palsy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.