Comparing Standard and Autoclaved Peanut Oral Immunotherapy in People With Peanut Allergy (NCT07439406)
Oral Immunotherapy Comparing Standard and Autoclaved Peanuts in Peanut-Allergic Individuals
🩺 Plain-English Summary (8th-Grade Level)
Peanut allergy can cause serious and potentially life-threatening allergic reactions. Oral immunotherapy (OIT) is an investigational treatment that involves giving small, gradually increasing amounts of peanut protein to help reduce allergic sensitivity. However, OIT may cause allergic reactions during treatment. This Phase II clinical trial will compare two forms of peanut used for oral immunotherapy: standard blanched peanuts and autoclaved peanuts (peanuts heated under high temperature and pressure to modify their proteins). Participants aged 4 to 30 years with confirmed peanut allergy will be randomly assigned to receive one of the two treatments. The study will evaluate safety, tolerability, adherence, and the ability to tolerate a higher amount of peanut protein after 12 months of therapy. The goal is to determine whether autoclaved peanuts provide a safer and better tolerated approach to peanut oral immunotherapy.
Who can join: Review the eligibility criteria below.
Location: The Centre for Innovative Medicine (CIM) at the Montreal Children's Hospital (MCH) — Montreal, Quebec
Age range: 4 Years to 30 Years
🧪 Interventions in This Study
- Autoclaved peanut oral immunotherapy (OTHER)
- Blanched peanut oral immunotherapy (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- The Centre for Innovative Medicine (CIM) at the Montreal Children's Hospital (MCH) — Montreal, Quebec
📞 Contact the Study Coordinator
Phone: (514) 934-1934
Email: bruce.mazer@mcgill.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Peanut Allergy
- Food Oral Immunotherapy for Peanut Allergy — Boston, Massachusetts
- A Safety and Efficacy Study of PVX108 in Children and Adolescents With Peanut Allergy — Little Rock, Arkansas
- Phase I Trial to Evaluate VLP Peanut in Healthy and Peanut Allergic Subjects — Tucson, Arizona
- Peanut and Tree Nut Desensitization — Toronto, Ontario
- Investigating Modified Protocols of Oral Immunotherapy to Validate Efficacy and Safety — Montreal, Quebec
Explore by condition: All Peanut Allergy clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.