A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use (NCT07446439)
The Thetis Study: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Tradipitant on Nausea and Vomiting After GLP-1R Agonist Administration in Healthy Overweight or Obese Volunteers
🩺 Plain-English Summary (8th-Grade Level)
The goal of this study is to measure the effects of using Tradipitant to treat nausea and vomiting induced by GLP-1R agonist use in adults with class I or class II obesity, or adults who are overweight with at least one weight-related condition. The study is placebo-controlled with two treatment arms.
Who can join: Review the eligibility criteria below.
Location: Vanda Investigational Site — Los Angeles, California
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (10 Sites)
- Vanda Investigational Site — Los Angeles, California
- Vanda Investigational Site — San Diego, California
- Vanda Investigational Site — San Jose, California
- Vanda Investigational Site — Tampa, Florida
- Vanda Investigational Site — Hamilton, New Jersey
- Vanda Investigational Site — New York, New York
- Vanda Investigational Site — Syosset, New York
- Vanda Investigational Site — Plano, Texas
- Vanda Investigational Site — San Antonio, Texas
- Vanda Investigational Site — Burke, Virginia
📞 Contact the Study Coordinator
Phone: (202) 734-3400
Email: clinicaltrials@vandapharma.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Nausea and Vomiting
- Broadening Antiemetics Research by Comparing the Effectiveness of Fosaprepitant and Metoclopramide — The Bronx, New York
- Antiemetic Fosaprepitant To Remedy Nausea and Vomiting — The Bronx, New York
Explore by condition: All Nausea and Vomiting clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.