🏛️ Verified NIH Record • Updated 2026-05-03
PVX4 for the Treatment of Human Papilloma Virus (HPV)16+ Cervical Dysplasia (NCT07454915)
🟢 Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: PapiVax Biotech, Inc.
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this Phase 2 study is to compare the effects of administering the PVX4 combination device biologic product (pBI-4 DNA vaccine via electroporation-mediated intramuscular delivery with the TriGrid™ Delivery System) in patients with biopsy-confirmed, human papilloma virus (HPV) 16-associated high grade cervical intraepithelial neoplasia (CIN2/3) as compared to the administration of placebo.
Who can join: Review the eligibility criteria below.
Location: Montefiore Medical Center — The Bronx, New York
Age range: 18 Years to 60 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (10 Sites)
- Montefiore Medical Center — The Bronx, New York
- Kaohsiung Chang Gung Memorial Hospital — Kaohsiung, Taiwan
- China Medical University Hospital — Taichung, Taiwan
- Taichung Veterans General Hospital — Taichung, Taiwan
- National Cheng Kung University Hospital — Tainan, Taiwan
- National Taiwan University Hospital — Taipei, Taiwan
- MacKay Memorial Hospital — Taipei, Taiwan
- Taipei Medical University Hospital — Taipei, Taiwan
- Taipei Veterans General Hospital — Taipei, Taiwan
- Linkou Chang Gung Memorial Hospital — Taoyuan, Taiwan
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Cervical Intraepithelial Neoplasia Grade 2/3 clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.