A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain (NCT07481630)
Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Knee Osteoarthritis (AMAZE 5)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and knee osteoarthritis. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Who can join: Review the eligibility criteria below.
Location: Arizona Research Center, Inc. — Phoenix, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (82 Sites)
Showing the first 25 of 82 sites.
- Arizona Research Center, Inc. — Phoenix, Arizona
- Diablo Clinical Research, Inc. — Walnut Creek, California
- Chase Medical Research LLC — Hamden, Connecticut
- Chase Medical Research LLC — Waterbury, Connecticut
- Zenith clinical research — Hollywood, Florida
- CNS Healthcare — Jacksonville, Florida
- Angels Clinical Research Institute — Miami Lakes, Florida
- Hope Clin Res & Wellness — Conyers, Georgia
- CenExel iResearch, LLC — Decatur, Georgia
- Elite Clinical Trials — Blackfoot, Idaho
- MedVadis Research Watertown — Waltham, Massachusetts
- Jubilee Clinical Research, Inc. — Las Vegas, Nevada
- Great Lakes Medical Research — Westfield, New York
- Accellacare and KDCILM, LLC — Wilmington, North Carolina
- Coastal Carolina Res Ctr — North Charleston, South Carolina
- VIP Trials_San Antonio — San Antonio, Texas
- Charlottesville Med Research — Charlottesville, Virginia
- Health Res of Hampton Roads — Newport News, Virginia
- Northwest Clinical Research Center — Bellevue, Washington
- Emeritus Research Sydney — Botany, New South Wales
- Momentum Clinical Research Darlinghurst — Darlinghurst, New South Wales
- Kolling Institute — St Leonards, New South Wales
- Heart of Australia — Chelmer, Queensland
- Coastal Digestive Health — Maroochydore, Queensland
- UMHAT Sveti Georgi EAD, Plovdiv — Plovdiv,
📞 Contact the Study Coordinator
Phone: (866) 867-7178
Email: clinicaltrials@novonordisk.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.