Identification of Objective Metabolomics-based Biomarkers of Yogurt Consumption (NCT07491887)
🩺 Plain-English Summary (8th-Grade Level)
Substantial evidence links yogurt consumption to a lower risk of type 2 diabetes (T2D). However, the existing evidence is derived exclusively from prospective cohort studies relying on self-reported dietary questionnaires, which-despite being validated-are subject to random and systematic errors that may compromise evidence quality and hinder regulatory approval. The project aims to discover and validate biomarkers of yogurt intake. The investigators will conduct a randomized, crossover, dose-response feeding trial involving 16 generally healthy adult participants (8 females, 8 males). The trial will include four 7-day diet periods, each separated by a 1-week washout. All diets will be based on a dairy-free background and supplemented with one of the following: (a) 1 serving of soy-based pudding (no yogurt), (b) 0.5 serving of yogurt, (c) 1 serving of yogurt, or (d) 2 servings of yogurt per 2,380 kcal/day. On the 7th day of each diet, participants will complete a mixed-meal test at INAF, consuming a smoothie containing the same yogurt dose as during the preceding days. Plasma samples collected in the postprandial state will be used to profile over 20,000 metabolites. Using artificial intelligence-based approaches, potential biomarkers of yogurt intake will be identified. These candidates will then be filtered using standard statistical methods to assess dose- and time-responsiveness, robustness, and biological plausibility. Biomarkers that meet all criteria will be considered validated indicators of yogurt intake.
Who can join: Review the eligibility criteria below.
Location: Institute on nutrition and functional foods, Laval University — Québec, Quebec
Age range: 18 Years to 70 Years
🧪 Interventions in This Study
- Yogurt-free diet (OTHER)
- Low-yogurt diet (OTHER)
- Moderate-yogurt diet (OTHER)
- High-yogurt diet (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Institute on nutrition and functional foods, Laval University — Québec, Quebec
📞 Contact the Study Coordinator
Phone: (418) 656-2131
Email: jean-philipe.drouin-chartier@pha.ulaval.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Diet
- Dietary Behavior Intervention in African Americans at Risk for Cardiovascular Disease — Bethesda, Maryland
- Increasing Affordable Fruits and Vegetables for Families With Food Insecurity — Columbia, South Carolina
Explore by condition: All Diet clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.