🏛️ Verified NIH Record • Updated 2026-06-23

MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial (NCT07505303)

A Phase 2a, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of ECC4703 as an Adjunct to Semaglutide in Adults With Obesity

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Eccogene

🩺 Plain-English Summary (8th-Grade Level)

The primary objective of this trial is to evaluate the effect of oral ECC4703 on body weight reduction and in a sub-study on liver fat content as assessed by change in magnetic resonance imaging proton density fat fraction (MRI-PDFF) at Week 20.

Who can join: Review the eligibility criteria below.

Location: Central Research Associates - Flourish - PPDS — Birmingham, Alabama

Age range: 18 Years to 75 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (15 Sites)

  • Central Research Associates - Flourish - PPDS — Birmingham, Alabama
  • Anaheim Clinical Trials LLC - Anaheim - CenExel - PPDS — Anaheim, California
  • Collaborative Neuroscience Network - Los Alamitos- CenExel - PPDS — Los Alamitos, California
  • AES - DRS - Optimal Research Florida - Melbourne — Melbourne, Florida
  • ForCare Clinical Research - CenExel FCR - PPDS — Tampa, Florida
  • Atlanta Center for Medical Research - CenExel ACMR - PPDS — Atlanta, Georgia
  • iResearch Atlanta - CenExel - PPDS — Decatur, Georgia
  • AES - DRS - Synexus Clinical Research US, Inc. - Richfield - Minneapolis — Richfield, Minnesota
  • Velocity Clinical Research (3345 N 107th St) - Omaha - Nebraska - PPDS — Omaha, Nebraska
  • Velocity Clinical Research - Durham - PPDS — Durham, North Carolina
  • Velocity Clinical Research - Cincinnati (Springdale) - Ohio - PPDS — Cincinnati, Ohio
  • Velocity Clinical Research - Providence - PPDS — East Greenwich, Rhode Island
  • Velocity Clinical Research - Dallas - PPDS — Dallas, Texas
  • AES - DRS - Synexus Clinical Research US, Inc. - San Antonio — San Antonio, Texas
  • Flourish Research - San Antonio - PPDS — San Antonio, Texas

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Adult Obesity clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗