IMAT Quality in Aging (NCT07506681)
Targeting Intramuscular Adipose Quality in Aging
🩺 Plain-English Summary (8th-Grade Level)
This study will test the central hypothesis that fat within the muscle, or intramuscular adipose tissue (IMAT), exhibits elevated damage and pro-inflammatory signaling with aging, both of which are reduced by progressive resistance exercise (PRE). Sixteen older adults 65-80 years old will be recruited and complete a 12 week calf PRE intervention. Calf muscle strength, composition (measured by computed tomography) and muscle biopsies will be collected before and after the intervention. Histology, transcriptomic and secretomic tests will be completed to assess signs of damage and inflammation.
Who can join: Review the eligibility criteria below.
Location: Washington University — St Louis, Missouri
Age range: 65 Years to 80 Years
🧪 Interventions in This Study
- Calf muscle strengthening (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Washington University — St Louis, Missouri
📞 Contact the Study Coordinator
Phone: (314) 286-1433
Email: hastingsmk@wustl.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Aging
- A Pilot Study on Reverse Aging (The REVERSE Study) — Cincinnati, Ohio
- Feasibility of Home-based tES for Older Adults at Risk of Falling — Roslindale, Massachusetts
- Heat, Microvascular Function and Aging — Milwaukee, Wisconsin
- Protein Quantity and Quality in Older Subjects — Hamilton, Ontario
- Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse — Salt Lake City, Utah
- Effect of a Daily Supplement on Plasma PAI-1 Levels — Los Angeles, California
Explore by condition: All Aging clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.