AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain (NCT07509307)
Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Knee Osteoarthritis (AMAZE 6)
🩺 Plain-English Summary (8th-Grade Level)
This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Who can join: Review the eligibility criteria below.
Location: Neighborhood Healthcare — Escondido, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (81 Sites)
Showing the first 25 of 81 sites.
- Neighborhood Healthcare — Escondido, California
- First Valley Medical Group — Lancaster, California
- Desert Oasis Healthcare — Palm Springs, California
- Chase Medical Research LLC — Waterbury, Connecticut
- Westside Center For Clinical Research — Jacksonville, Florida
- Clinical Neuroscience Solutions, LLC — Jacksonville, Florida
- Advanced Res for Health Improve — Naples, Florida
- Clinical Investigation Spec Gurnee — Gurnee, Illinois
- Evanston Premier Hlthcr Res — Skokie, Illinois
- Monroe Biomedical Research, LLC — Louisville, Kentucky
- Arcturus Healthcare, PLC. — Troy, Michigan
- Clinvest Research — Springfield, Missouri
- NYU Langone Orthopedic Center — New York, New York
- Hospital For Special Surgery — New York, New York
- Piedmont Healthcare/Research — Statesville, North Carolina
- Northwest Research Center — Portland, Oregon
- Mercy Family Clinic — Dallas, Texas
- Health Res of Hampton Roads — Newport News, Virginia
- Northwest Clinical Research Center — Bellevue, Washington
- Emeritus Research Sydney — Botany, New South Wales
- Momentum Clinical Research Darlinghurst — Darlinghurst, New South Wales
- Kolling Institute — St Leonards, New South Wales
- Heart of Australia — Chelmer, Queensland
- Coastal Digestive Health — Maroochydore, Queensland
- UMHAT Sveti Georgi EAD, Plovdiv — Plovdiv,
📞 Contact the Study Coordinator
Phone: (866) 867-7178
Email: clinicaltrials@novonordisk.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.