AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight (NCT07533175)
Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Type 2 Diabetes (AMAZE 2)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and type 2 diabetes. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Who can join: Review the eligibility criteria below.
Location: Univ of Alabama Birmingham — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (74 Sites)
Showing the first 25 of 74 sites.
- Univ of Alabama Birmingham — Birmingham, Alabama
- Headlands Research California, LLC — Escondido, California
- Torrance Clinical Research Institute, Inc. — Lomita, California
- Diablo Clinical Research, Inc. — Walnut Creek, California
- Northeast Research Institute — Fleming Island, Florida
- Jacksonville Ctr Clin Res — Jacksonville, Florida
- Florida Institute for Clinical Research, LLC — Orlando, Florida
- Oviedo Medical Research, LLC — Oviedo, Florida
- International Diabetes Center — Minneapolis, Minnesota
- Southgate Medical Group, LLP — West Seneca, New York
- Spartanburg Medical Research — Spartanburg, South Carolina
- M3 Wake Research Chattanooga — Chattanooga, Tennessee
- UT Southwestern Med Center — Dallas, Texas
- PlanIt Research, PLLC — Houston, Texas
- National Clin Res Inc. — Richmond, Virginia
- MICA- Medicina e Investigación Cardiometabólica — Manuel Alberti, Buenos Aires
- Kynet Recoleta — Buenos Aires,
- Centro médico privado Cemaic — Córdoba,
- CEDIR - Centro de diagnóstico y rehabilitación Santa Fe — Santa Fe,
- Cline Research Center — Curitiba, Paraná
- PUCCAMP - Hospital e Maternidade Celso Pierro — Campinas, São Paulo
- CPCLIN - Centro de Pesquisas Clínicas — São Paulo, São Paulo
- Centro de Pesquisa Clínica do Hospital das Clínicas da Faculdade de Medicina da USP — São Paulo, São Paulo
- Opca bolnica Karlovac — Karlovac,
- Specijalna Bolnica za medicinsku rehabilitaciju Krapinske Toplice_Endocrinology — Krapinske Toplice,
📞 Contact the Study Coordinator
Phone: (866) 867-7178
Email: clinicaltrials@novonordisk.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.