🏛️ Verified NIH Record • Updated 2026-07-31
A Study of Weekly Oral Dose of Ecnoglutide (VRB-101) for Weight Maintenance in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (NCT07553299)
A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study to Identify the Optimal Weekly Oral Dose of Ecnoglutide (VRB-101) for Maintaining Body Weight in Participants With Obesity or Overweight Who Have Weight-Related Comorbidities
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Verdiva Bio Dev Limited
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to identify the weekly oral dose of VRB-101 (oral ecnoglutide) that can effectively maintain body weight in participants with a history of obesity or overweight with weight-related comorbidities.
Who can join: Review the eligibility criteria below.
Location: Clinical Study Site 202 — Cullman, Alabama
Age range: 18 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (20 Sites)
- Clinical Study Site 202 — Cullman, Alabama
- Clinical Study Site 203 — Phoenix, Arizona
- Clinical Study Site 212 — Tempe, Arizona
- Clinical Study Site 201 — Little Rock, Arkansas
- Clinical Study Site 214 — Santa Maria, California
- Clinical Study Site 216 — Stamford, Connecticut
- Clinical Study Site 204 — Bradenton, Florida
- Clinical Study Site 221 — Orange City, Florida
- Clinical Study Site 215 — St. Petersburg, Florida
- Clinical Study Site 219 — Niles, Illinois
- Clinical Study Site 213 — El Dorado, Kansas
- Clinical Study Site 210 — Petal, Mississippi
- Clinical Study Site 205 — Buffalo, New York
- Clinical Study Site 206 — Lenoir, North Carolina
- Clinical Study Site 220 — Oklahoma City, Oklahoma
- Clinical Study Site 209 — Jackson, Tennessee
- Clinical Study Site 217 — Houston, Texas
- Clinical Study Site 211 — Houston, Texas
- Clinical Study Site 218 — Irving, Texas
- Clinical Study Site 207 — Richmond, Virginia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.