SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury (NCT07560631)
SeeMe: A Multimodal Behavioral-Electrophysiological Tool for Real-Time Detection of Motor Behavior in Brain Injury Patients
🩺 Plain-English Summary (8th-Grade Level)
Objective: This prospective interventional study introduces "SeeMe," an automated, high-resolution computer vision platform designed to objectively quantify microscopic, auditory command-evoked movements in patients with Traumatic Brain Injury (TBI). Current clinical assessments, such as the Glasgow Coma Scale (GCS) and Coma Recovery Scale-Revised (CRS-R), rely on subjective human observation and often fail to detect low-amplitude motor responses, potentially misclassifying up to 25% of patients as unresponsive. Methodology: SeeMe utilizes vector analysis, cross-correlation, and deep neural networks (DNNs) to track individual facial pores and hand movements with sub-millimeter precision (0.5 mm) and high temporal resolution (0.03s). The study will enroll a cohort of 60-80 TBI patients, alongside healthy controls and pharmacologically paralyzed subjects, to validate SeeMe's sensitivity and specificity. Primary Goals: 1. Validation: Compare SeeMe's detection of voluntary motor recovery against gold-standard clinical examinations (CRS-R). 2. Synchronization: Simultaneously record and time-lock electroencephalography (EEG) and electrocorticography (ECoG) with SeeMe-detected movements. 3. Biomarker Identification: Characterize neural signatures (specifically Beta-band oscillations) associated with the return of voluntary behavior. Impact: By providing a real-time, objective measure of motor intention and execution, SeeMe aims to identify "Cognitive-Motor Dissociation" (CMD) earlier than current methods, facilitating more accurate prognostications and laying the framework for future closed-loop neuromodulation (e.g., Vagus Nerve Stimulation) to accelerate TBI recovery.
Who can join: Review the eligibility criteria below.
Location: Stony Brook University Hospital — Stony Brook, New York
Age range: 22 Years to 85 Years
🧪 Interventions in This Study
- SeeMe Multimodal Auditory Command Protocol (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Stony Brook University Hospital — Stony Brook, New York
📞 Contact the Study Coordinator
Phone: (631) 444-1278
Email: sima.mofakham@stonybrookmedicine.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Traumatic Brain Injury (TBI) Patients
- Transcutaneous Vagus Nerve Stimulation for Attention and Memory — Houston, Texas
- Home-Based Walking for Thinking Skills in Persons With TBI — East Hanover, New Jersey
- Early Neuromodulation in Traumatic Brain Injury — Cincinnati, Ohio
- Effect of Fixation Training With Colored Light Targets on Traumatic Brain Injury-Associated Photophobia — Columbus, Ohio
- Multimodal, Enriched Environment for Rehabilitation in Chronic Traumatic Brain Injury — Cleveland, Ohio
Explore by condition: All Traumatic Brain Injury (TBI) Patients clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.