Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression (NCT07563868)
🩺 Plain-English Summary (8th-Grade Level)
This study is being conducted at Massachusetts General Hospital (MGH) to explore whether adding psychedelic coaching can enhance the effects of ketamine or esketamine maintenance treatment in individuals with treatment-resistant depression (TRD). The investigators are currently enrolling participants who are receiving ongoing maintenance intravenous (IV) ketamine or intranasal esketamine (Spravato) treatment at the MGH Ketamine Clinic. Participation in the study will involve adding coaching sessions to your existing ketamine maintenance treatment.
Who can join: Review the eligibility criteria below.
Location: Massachusetts General Hospital's Depression and Clinical Research program — Boston, Massachusetts
Age range: 18 Years
🧪 Interventions in This Study
- Psychedelic Integration Coaching (BEHAVIORAL)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (2 Sites)
- Massachusetts General Hospital's Depression and Clinical Research program — Boston, Massachusetts
- Massachusetts General Hospital — Boston, Massachusetts
📞 Contact the Study Coordinator
Phone: (617) 643-4897
Email: mnyer@mgh.harvard.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Treatment Resistant Depression (TRD)
- Ketamine Biomarker Validation — New York, New York
- Neuronavigated aiTBS for TRD — San Diego, California
- Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression — Rochester, New York
- Lumateperone for Late-Life Depression — Tucson, Arizona
- Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study — San Diego, California
Explore by condition: All Treatment Resistant Depression (TRD) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.