A Trial to Evaluate the Safety and Tolerability of DV700P-RNA and DV701B1.1-RNA Immunization in Combination With Antiretroviral Analytical Treatment Interruption (ATI) in People Living With HIV for Elicitation of V3-glycan Antibodies (NCT07569029)
A Nonrandomized Phase 1 Clinical Trial to Evaluate the Safety and Tolerability of DV700P-RNA and DV701B1.1-RNA Immunization in Combination With Antiretroviral Analytical Treatment Interruption (ATI) in People Living With HIV for Elicitation of V3-glycan Antibodies
🩺 Plain-English Summary (8th-Grade Level)
This phase 1 study will evaluate the safety, tolerability, and immune responses of two experimental mRNA HIV vaccines in adults living with HIV who are in overall good health. The study will enroll about 42 participants at multiple study sites. Researchers will assess whether these vaccines can start or strengthen antibody responses against HIV. The study will also evaluate how a closely monitored planned pause in antiretroviral therapy affects these immune responses.
Who can join: Review the eligibility criteria below.
Location: Alabama CRS (Site ID: 31788) — Birmingham, Alabama
Age range: 18 Years to 60 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (19 Sites)
- Alabama CRS (Site ID: 31788) — Birmingham, Alabama
- Bridge HIV CRS (Site#: 30305) — San Francisco, California
- The Ponce de Leon Center CRS (Site ID: 5802) — Atlanta, Georgia
- The Hope Clinic of the Emory Vaccine Center CRS (Site #: 31440) — Decatur, Georgia
- Beth Israel Deaconess Medical Center / BIDMC VCRS (Site ID: 32077) — Boston, Massachusetts
- Brigham and Women's Hospital Vaccine CRS (BWH VCRS) (Site#: 30007) — Boston, Massachusetts
- Columbia P&S CRS (Site#: 30329) — New York, New York
- University of Rochester Vaccines to Prevent HIV Infection CRS (Site#: 31467) — Rochester, New York
- Penn Prevention CRS (Site#: 30310) — Philadelphia, Pennsylvania
- University of Pittsburgh CRS (Site#: 1001) — Pittsburgh, Pennsylvania
- Houston Advancing Research Team CRS (Site # 31473) — Houston, Texas
- Seattle Vaccine and Prevention CRS (Site ID: 30331) — Seattle, Washington
- Fundacion Huesped CRS (Site ID: 31957) — Buenos Aires,
- Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales CRS (CITBM) - Unidad de Ensayos Clínicos (UNIDEC) (Site ID: 31970) — Bellavista, Provincia Constitucional del Callao
- Via Libre CRS (Site ID: 31909) — Lima,
- Barranco CRS (Site ID: 11301) — Lima,
- San Miguel CRS (Site ID: 11302) — Lima,
- Seke South CRS/30294 University of Zimbabwe -Clinical Trials Research Centre (UZ-CTRC) — Harare,
- Spilhaus CRS/30314 University of Zimbabwe -Clinical Trials Research Centre (UZ-CTRC) — Harare,
📞 Contact the Study Coordinator
Phone: (205) 873-8686
Email: heatherlogan@uabmc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.