AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea (NCT07571005)
Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure (AMAZE 3)
🩺 Plain-English Summary (8th-Grade Level)
This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with excess body weight and obstructive sleep apnoea not treated with positive airway pressure lose weight and improve sleep apnoea. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.
Who can join: Review the eligibility criteria below.
Location: Artemis Insitute for Clin Res — San Diego, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (80 Sites)
Showing the first 25 of 80 sites.
- Artemis Insitute for Clin Res — San Diego, California
- PharmaDev Clinical Research Institute LLC — Miami, Florida
- Essence MD Research — Naples, Florida
- Renstar Medical Research — Ocala, Florida
- Conquest Research — Atlanta, Georgia
- Physicians Research Associates — Lawrenceville, Georgia
- University Of Chicago — Chicago, Illinois
- Weil Cornell Medicine — New York, New York
- CTI Clinical Research Center — Cincinnati, Ohio
- Clinical Research Associates of Central PA, LLC — DuBois, Pennsylvania
- Epic Medical Research — DeSoto, Texas
- Advanced Neurology Epilepsy and Sleep Center ANESC — El Paso, Texas
- Biorhythms Center for Integrative Sleep Medicine — El Paso, Texas
- Houston Pulmonary Medicine Associates, PA and Research Physicians Network, LLC — Houston, Texas
- Sleep Therapy Research Center — San Antonio, Texas
- Tricoastal Sleep Center — Sugar Land, Texas
- Rainier Clin Res Ctr Inc — Renton, Washington
- Woolcock Institute — Macquarie Park, New South Wales
- University of Sunshine Coast - Vitality Village — Birtinya, Queensland
- Mater Research - RIO Clinical Trials Unit — South Brisbane, Queensland
- Nightingale Research — Adelaide, South Australia
- University of Western Australia - Centre for Sleep Science — Crawley, Western Australia
- Peking University People's Hospital-Endocrinology — Beijing, Beijing Municipality
- The Second Affiliated Hospital of Nanjing Medical University-Endocrinology — Nanjing, Jiangsu
- The First Affiliated Hospital of Soochow University-Endocrinology — Suzhou, Jiangsu
📞 Contact the Study Coordinator
Phone: (866) 867-7178
Email: clinicaltrials@novonordisk.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.