AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea (NCT07571109)
Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Obstructive Sleep Apnoea Treated With Positive Airway Pressure (AMAZE 4)
🩺 Plain-English Summary (8th-Grade Level)
This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with overweight or obesity, and obstructive sleep apnoea treated with positive airway pressure. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.
Who can join: Review the eligibility criteria below.
Location: Dignity Health, Mercy Gilbert — Gilbert, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (92 Sites)
Showing the first 25 of 92 sites.
- Dignity Health, Mercy Gilbert — Gilbert, Arizona
- DM Clinical — Bradenton, Florida
- Essence MD Research — Naples, Florida
- Palm Beach Research Center — West Palm Beach, Florida
- NeuroTrials Research, Inc. — Atlanta, Georgia
- Physicians Research Associates — Lawrenceville, Georgia
- Chicago Research Center, Inc — Chicago, Illinois
- Weil Cornell Medicine — New York, New York
- Lillestol Research LLC — Fargo, North Dakota
- CTI Clinical Research Center — Cincinnati, Ohio
- Clinical Research Associates of Central PA, LLC — DuBois, Pennsylvania
- Bogan Sleep Consultants, LLC — Columbia, South Carolina
- Epic Medical Research — DeSoto, Texas
- Advanced Neurology Epilepsy and Sleep Center ANESC — El Paso, Texas
- Biorhythms Center for Integrative Sleep Medicine — El Paso, Texas
- Houston Pulm Med Res Network — Houston, Texas
- Sleep Therapy Research Center — San Antonio, Texas
- Tricoastal Sleep Center — Sugar Land, Texas
- Rainier Clin Res Ctr Inc — Renton, Washington
- Seattle Clinical Research Center — Seattle, Washington
- Woolcock Institute — Macquarie Park, New South Wales
- University of Sunshine Coast - Vitality Village — Birtinya, Queensland
- Mater Research - RIO Clinical Trials Unit — South Brisbane, Queensland
- Nightingale Research Adelaide — Adelaide, South Australia
- University of Western Australia - Centre for Sleep Science — Crawley, Western Australia
📞 Contact the Study Coordinator
Phone: (866) 867-7178
Email: clinicaltrials@novonordisk.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.