A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder (NCT07573176)
A Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate Efficacy and Safety of Seltorexant as Monotherapy in Adult and Elderly Participants With Major Depressive Disorder (MDD) and an Open-label Long-term Extension Treatment With Seltorexant
🩺 Plain-English Summary (8th-Grade Level)
The main purpose of this study is to assess how well the study drug (JNJ-42847922) works (efficacy) compared with placebo in improving depressive symptoms in participants with major depressive disorder (\[MDD\], a common mood disorder that causes a lasting feeling of sadness and a loss of interest in everyday activities) in double-blind treatment phase. Further, to evaluate long-term safety and tolerability of JNJ-42847922 in participants with MDD in the open label treatment phase.
Who can join: Review the eligibility criteria below.
Location: SanRo Clinical Research Group LLC WCG Clinical Network — Bryant, Arkansas
Age range: 18 Years to 74 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (39 Sites)
Showing the first 25 of 39 sites.
- SanRo Clinical Research Group LLC WCG Clinical Network — Bryant, Arkansas
- CI Trials — Bellflower, California
- Behavioral Research Specialists LLC — Glendale, California
- Excell Research Inc — Oceanside, California
- NRC Research Institute — Orange, California
- Cenexel — Riverside, California
- Sunwise Clinical Research — Walnut Creek, California
- UHC Research — Doral, Florida
- Reliable Clinical Research — Hialeah, Florida
- Nuovida Research Center — Miami, Florida
- IPTB Clinical Research — Tampa, Florida
- Health Synergy Clinical Research — West Palm Beach, Florida
- Agile Clinical Research Trials, LLC — Atlanta, Georgia
- Accelerated Clinical Research Group LLC — Snellville, Georgia
- Chicago Research Center — Chicago, Illinois
- Pharmasite Research, Inc. — Baltimore, Maryland
- Adams Clinical Boston — Boston, Massachusetts
- Adams Clinical Watertown — Watertown, Massachusetts
- CenExel Marlton NJ — Marlton, New Jersey
- Integrative Clinical Trials LLC — Brooklyn, New York
- SPRI Clinical Trials, LLC — Brooklyn, New York
- Bioscience Research LLC — Mount Kisco, New York
- Fieve Clinical Research Inc — New York, New York
- Adams Clinical Harlem — New York, New York
- Manhattan Behavioral Medicine — New York, New York
📞 Contact the Study Coordinator
Phone: (844) 434-4210
Email: Participate-In-This-Study1@its.jnj.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Depressive Disorder, Major
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- Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab — Boston, Massachusetts
- bWell-D Pilot Randomized Controlled Trial — Vancouver, British Columbia
- Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation — Belmont, Massachusetts
- Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms — Birmingham, Alabama
Explore by condition: All Depressive Disorder, Major clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.