🏛️ Verified NIH Record • Updated 2026-08-11
HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB (NCT07575308)
HMBeacon: A Phase 2, Randomized, Double-blind Study of the Safety, Tolerability, Efficacy, and Pharmacodynamics of Multiple Dose ALN-6400 in Adult and Adolescent Female Patients With Von Willebrand Disease (VWD) and Heavy Menstrual Bleeding (HMB)
🟢 Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Alnylam Pharmaceuticals
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the safety, tolerability, efficacy, and pharmacodynamics (PD) of multiple doses of ALN-6400 in adult and adolescent patients with VWD and HMB
Who can join: Review the eligibility criteria below.
Location: Clinical Trial Site — Los Angeles, California
Age range: 16 Years to 45 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (4 Sites)
- Clinical Trial Site — Los Angeles, California
- Clinical Trial Site — Orange, California
- Clinical Trial Site — Miami, Florida
- Clinical Trial Site — Lexington, Kentucky
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Von Willebrand Disease (VWD)
- A Study of Bleeding and Treatment in Participants With Von Willebrand Disease — Phoenix, Arizona
- A Study Assessing HMB-002 in Participants With Von Willebrand Disease — Phoenix, Arizona
- Study to Evaluate Subcutaneous (SC) VGA039 in Patients With Von Willebrand Disease (VWD) — Little Rock, Arkansas
- A Study of Vonicog Alfa (rVWF) in Children With Severe Von Willebrand Disease (vWD) — Birmingham, Alabama
Explore by condition: All Von Willebrand Disease (VWD) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.