A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1) (NCT07575932)
A PHASE 2B, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, DOSE RANGING, DOSE-FINDING, UMBRELLA STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-08653945 AND PF-08653944, ALONE OR IN COMBINATION, IN ADULTS WITH OVERWEIGHT OR OBESITY (SOLIS-1)
🩺 Plain-English Summary (8th-Grade Level)
This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).
Who can join: Review the eligibility criteria below.
Location: Arizona Clinical Trials-Chandler — Chandler, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (65 Sites)
Showing the first 25 of 65 sites.
- Arizona Clinical Trials-Chandler — Chandler, Arizona
- Clinical Research Institute of Arizona — Sun City West, Arizona
- Arizona Clinical Trials (ACT) - Tucson — Tucson, Arizona
- San Fernando Valley Health Institute — Canoga Park, California
- Ark Clinical Research — Fountain Valley, California
- Paragon Rx Clinical — Garden Grove, California
- Torrance Clinical Research Institute, Inc. — Lomita, California
- Ark Clinical Research — Long Beach, California
- Collaborative Neuroscience Research, LLC — Los Alamitos, California
- Paradigm Clinical Research-Modesto — Modesto, California
- Paradigm Clinical Research Centers, LLC — San Diego, California
- University Clinical Investigators, Incorporated — Tustin, California
- Diablo Clinical Research, LLC dba Flourish Research — Walnut Creek, California
- AGA Clinical Trials — Hialeah, Florida
- Westside Center for Clinical Research — Jacksonville, Florida
- New Horizon Research Center — Miami, Florida
- Charter Research — Orlando, Florida
- Atlanta Diabetes Associates — Atlanta, Georgia
- Clinical Research Atlanta — Stockbridge, Georgia
- Koch Family Medicine Clinical Research/Elite Research Network — Morton, Illinois
- Bioluminux Clinical Research Illinois — Naperville, Illinois
- Johnson County Clinical Trials — Lenexa, Kansas
- DelRicht Research — Mandeville, Louisiana
- DelRicht Research — Prairieville, Louisiana
- Patient First Clinical Trials (PFCTRIALS) — Lutherville, Maryland
📞 Contact the Study Coordinator
Phone: (800) 718-1021
Email: ClinicalTrials.gov_Inquiries@pfizer.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Overweight
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- A Research Study to Compare Blood Levels of Two Different Versions of Cagrilintide in Adults With Excess Body Weight — Tempe, Arizona
- A Research Study on How Well Different Doses of the Medicine NNC0662-0419 Help People Living With Overweight or Obesity — Tempe, Arizona
- Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0 — Boston, Massachusetts
- Impact of Metabolic Health on Sperm Epigenetic Marks in Humans — Boston, Massachusetts
- The Effects of Almond Consumption on Functional Performance and Activity in Overweight Active Older Adults — Tallahassee, Florida
Explore by condition: All Overweight clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.