RP-008 in Combination With Daily Oral Varenicline for the Treatment of Trigeminal Neuralgia (NCT07596485)
A Phase 1/2, Multicenter, Open-Label Study to Evaluate Safety, Tolerability, and PRELIminary EFficacy of Percutaneous Injection of RP-008 Followed by Daily Oral Varenicline in Patients With Trigeminal Neuralgia (The RELIEF Study)
🩺 Plain-English Summary (8th-Grade Level)
The goal of this study is to evaluate if KRIYA-748 (RP-008) is safe, tolerable, and preliminary effective in treating trigeminal neuralgia (TN) when used in combination with varenicline tartrate. The study will also assess what doses of RP-008 are safe and tolerable for participants and how the severity of participants' TN pain and frequency of facial pain attacks are affected.
Who can join: Review the eligibility criteria below.
Location: Kriya Clinical Study Site — Sherbrooke
Age range: 18 Years to 80 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Kriya Clinical Study Site — Sherbrooke,
📞 Contact the Study Coordinator
Phone: (984) 884-5058
Email: clinicaltrials@kriyatx.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Trigeminal Neuralgia
- MR Guided Focused Ultrasound (FUS) for the Treatment of Trigeminal Neuralgia — Baltimore, Maryland
- RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery — Birmingham, Alabama
- An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia. — La Jolla, California
- Post-Operative Trigeminal Pain After Microvascular Decompression for Trigeminal Neuralgia — Newark, New Jersey
- Trigeminal Evoked Responses to Improve Rhizotomy — Minneapolis, Minnesota
Explore by condition: All Trigeminal Neuralgia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.