๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-04

A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia (NCT07623200)

A Phase 3, Randomized, Open-Label Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia and a CALR Mutation Previously Treated With Cytoreductive Therapy (EXCALIBUR-ET2)

๐ŸŸข Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Incyte Corporation

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This study is being conducted to evaluate INCA033989 versus best available therapy in participants with essential thrombocythemia and a CALR mutation previously treated with cytoreductive therapy.

Who can join: Review the eligibility criteria below.

Location: Banner Md Anderson Cancer Center โ€” Gilbert, Arizona

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (180 Sites)

Showing the first 25 of 180 sites.

  • Banner Md Anderson Cancer Center โ€” Gilbert, Arizona
  • The University of Arizona Cancer Center โ€” Tucson, Arizona
  • City of Hope Medical Center โ€” Duarte, California
  • Marin Cancer Care โ€” Greenbrae, California
  • University of California, Los Angeles Medical Center โ€” Los Angeles, California
  • Stanford Cancer Center โ€” Palo Alto, California
  • UCSF โ€” San Francisco, California
  • Rocky Mountain Cancer Centers-Lone Tree โ€” Lone Tree, Colorado
  • Medstar Georgetown Medical Center, Inc โ€” Washington D.C., District of Columbia
  • Florida Cancer Specialists & Research Institute โ€” Fort Myers, Florida
  • University of Miami Sylvester Comprehensive Cancer Center โ€” Miami, Florida
  • Cleveland Clinic โ€” Weston, Florida
  • Winship Cancer Institute of Emory University โ€” Atlanta, Georgia
  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University โ€” Chicago, Illinois
  • University of Chicago โ€” Chicago, Illinois
  • The University of Kansas Cancer Center โ€” Westwood, Kansas
  • Johns Hopkins Medicine-the Sidney Kimmel Comprehensive Cancer Center โ€” Baltimore, Maryland
  • Maryland Oncology Hematology, P.A. โ€” Columbia, Maryland
  • Massachusetts General Hospital โ€” Boston, Massachusetts
  • Beth Israel Deaconess Medical Center (Bidmc) โ€” Boston, Massachusetts
  • University of Massachusetts Medical School โ€” Worcester, Massachusetts
  • University of Michigan Rogel Cancer Center Adult Bone Marrow Transplant Clinic โ€” Ann Arbor, Michigan
  • Missouri Cancer Associates โ€” Columbia, Missouri
  • Washington University School of Medicine โ€” St Louis, Missouri
  • John Theurer Cancer Center, Hackensack University Medical Center โ€” Hackensack, New Jersey

๐Ÿ“ž Contact the Study Coordinator

Phone: (855) 463-3463

Email: medinfo@incyte.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—