A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia (NCT07623200)
A Phase 3, Randomized, Open-Label Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia and a CALR Mutation Previously Treated With Cytoreductive Therapy (EXCALIBUR-ET2)
๐ฉบ Plain-English Summary (8th-Grade Level)
This study is being conducted to evaluate INCA033989 versus best available therapy in participants with essential thrombocythemia and a CALR mutation previously treated with cytoreductive therapy.
Who can join: Review the eligibility criteria below.
Location: Banner Md Anderson Cancer Center โ Gilbert, Arizona
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (180 Sites)
Showing the first 25 of 180 sites.
- Banner Md Anderson Cancer Center โ Gilbert, Arizona
- The University of Arizona Cancer Center โ Tucson, Arizona
- City of Hope Medical Center โ Duarte, California
- Marin Cancer Care โ Greenbrae, California
- University of California, Los Angeles Medical Center โ Los Angeles, California
- Stanford Cancer Center โ Palo Alto, California
- UCSF โ San Francisco, California
- Rocky Mountain Cancer Centers-Lone Tree โ Lone Tree, Colorado
- Medstar Georgetown Medical Center, Inc โ Washington D.C., District of Columbia
- Florida Cancer Specialists & Research Institute โ Fort Myers, Florida
- University of Miami Sylvester Comprehensive Cancer Center โ Miami, Florida
- Cleveland Clinic โ Weston, Florida
- Winship Cancer Institute of Emory University โ Atlanta, Georgia
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University โ Chicago, Illinois
- University of Chicago โ Chicago, Illinois
- The University of Kansas Cancer Center โ Westwood, Kansas
- Johns Hopkins Medicine-the Sidney Kimmel Comprehensive Cancer Center โ Baltimore, Maryland
- Maryland Oncology Hematology, P.A. โ Columbia, Maryland
- Massachusetts General Hospital โ Boston, Massachusetts
- Beth Israel Deaconess Medical Center (Bidmc) โ Boston, Massachusetts
- University of Massachusetts Medical School โ Worcester, Massachusetts
- University of Michigan Rogel Cancer Center Adult Bone Marrow Transplant Clinic โ Ann Arbor, Michigan
- Missouri Cancer Associates โ Columbia, Missouri
- Washington University School of Medicine โ St Louis, Missouri
- John Theurer Cancer Center, Hackensack University Medical Center โ Hackensack, New Jersey
๐ Contact the Study Coordinator
Phone: (855) 463-3463
Email: medinfo@incyte.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Essential Thrombocythemia
- Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007) โ Glendale, Arizona
- A Single-arm, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of P1101 in Adults With ET โ Birmingham, Alabama
- Ropeginterferon Alfa-2b (P1101) vs. Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerance โ Scottsdale, Arizona
- IMG-7289 in Patients With Essential Thrombocythemia (ET) or Polycythemia Vera (PV) โ Miami, Florida
- A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006) โ Glendale, Arizona
- Ruxolitinib in Thrombocythemia and Polycythemia Vera โ Boston, Massachusetts
Explore by condition: All Essential Thrombocythemia clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.