IO Vancomycin Administration in TKA (NCT07633418)
Systemic Vancomycin Levels in Intraosseous Administration During Total Knee Arthroplasty
🩺 Plain-English Summary (8th-Grade Level)
This is a prospective, single-center, open-label study evaluating systemic vancomycin levels following preoperative intraosseous administration in patients undergoing primary unilateral total knee arthroplasty. Eligible participants will receive preoperative intraosseous vancomycin (500 mg in 100 mL saline) as part of standard perioperative infection prophylaxis. The study is open-label due to the nature of the intervention. Blood samples will be collected at predefined time points intraoperatively to measure serum vancomycin concentrations. Patients will be randomized to either a tourniquet or no tourniquet for these blood draws.
Who can join: Review the eligibility criteria below.
Location: UC San Diego — San Diego, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- UC San Diego — San Diego, California
📞 Contact the Study Coordinator
Phone: (858) 534-8268
Email: jbaun@health.ucsd.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Total Knee Arthroplasty
- Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty — Coon Rapids, Minnesota
- NitrX Total Knee Arthroplasty RSA — London, Ontario
- Bicruciate-retaining (2C) Total Knee Arthroplasty (TKA) Versus Posterior-stabilized (PS) Total Knee Arthroplasty (TKA) — Montreal, Quebec
- Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts — Edina, Minnesota
- Incidence of Adductor Canal Catheter Dislodgment — Toronto, Ontario
Explore by condition: All Total Knee Arthroplasty clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.