PET-Enabled Dual-Energy CT in Multiple Myeloma (NCT07646873)
PET-enabled Dual-energy CT for Oncological Applications
🩺 Plain-English Summary (8th-Grade Level)
This pilot study will evaluate a new imaging method called PET-enabled dual-energy CT for measuring bone and soft-tissue composition in bone marrow. The study will enroll adults with multiple myeloma who are scheduled to receive CAR T-cell therapy and healthy adult participants. All participants will undergo research imaging with dynamic 18F-FDG PET/CT and X-ray dual-energy CT. Participants with multiple myeloma will have imaging before CAR T-cell therapy and again after therapy. Healthy participants will have one imaging visit. The main goal is to compare bone and soft-tissue fraction measurements from PET-enabled dual-energy CT with measurements from standard X-ray dual-energy CT. The study will also explore whether corrected PET measurements are associated with bone marrow measurable residual disease, treatment response, and CAR T-cell therapy toxicities in participants with multiple myeloma. This study is not expected to provide direct medical benefit to participants. The information learned may help improve future PET/CT imaging methods for cancer evaluation.
Who can join: Review the eligibility criteria below.
Location: UC Davis EXPLORER Molecular Imaging Center — Sacramento, California
Age range: 18 Years
🧪 Interventions in This Study
- PET-enabled dual-energy CT imaging (DIAGNOSTIC_TEST)
- X-ray dual-energy CT imaging (DIAGNOSTIC_TEST)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- UC Davis EXPLORER Molecular Imaging Center — Sacramento, California
📞 Contact the Study Coordinator
Phone: (916) 731-9004
Email: research-radiology-som@health.ucdavis.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Multiple Myeloma (MM)
- Neurocognitive Trajectories After BCMA CAR-T — Charlotte, North Carolina
- MMulti-Immune HR; Multi-Target Immunotherapy for High-Risk Multiple Myeloma — Little Rock, Arkansas
- A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects — Gilbert, Arizona
- Moving Forward With Myeloma: A Lifestyle Intervention for Individuals With Multiple Myeloma — Maywood, Illinois
- A Study of Elranatamab Outpatient Administration in Patients With Relapsed/Refractory Multiple Myeloma — Denver, Colorado
Explore by condition: All Multiple Myeloma (MM) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.