A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults (NCT07679282)
Comparative Effectiveness of Positive Airway Pressure Therapy, Dental Device, and Atomoxetine-Oxybutynin for Sleep Apnea: the ADAPT-OSA Study
🩺 Plain-English Summary (8th-Grade Level)
Researchers want to identify which treatments for obstructive sleep apnea (OSA) work best and are easiest for patients to use consistently. Eligible participants will be randomly assigned one of three OSA treatments: traditional PAP therapy, a dental device, or a combination of two FDA-approved medications (atomoxetine and oxybutynin) that are currently approved for other conditions. Over the course of one year, participants will attend two in-person visits and take part in four phone check-ins to complete surveys, report any side effects, and discuss how well they are following their assigned treatment.
Who can join: Review the eligibility criteria below.
Location: Banner University Medical Center Tucson — Tucson, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (4 Sites)
- Banner University Medical Center Tucson — Tucson, Arizona
- Stanford Medical Center — Redwood City, California
- University of Miami Miller School of Medicine — Miami, Florida
- University of Maryland Baltimore — Baltimore, Maryland
📞 Contact the Study Coordinator
Phone: (520) 626-5287
Email: herickso@arizona.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Obstructive Sleep Apnea (OSA)
- The Impact of Technology in Obstructive Sleep Apnea Myofunctional Therapy — Cleveland, Ohio
- Assessing the Validity of the PAP Problems Triage Tool in Patients With PAP Treatment for Obstructive Sleep Apnea — Fontana, California
- Overnight Polysomnography and Respiratory Volume Monitor — Boston, Massachusetts
- CPAP vs High-Flow Nasal Cannula for Treating Sleep Apnea in Children — Toronto, Ontario
- CPAP Randomized Controlled Trial — Toronto, Ontario
Explore by condition: All Obstructive Sleep Apnea (OSA) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.